血竭化学成分、药理作用研究进展及其质量标志物（Q-Marker）预测

Research progress on chemical constituents, pharmacological effects of Draconis Sanguis and its quality marker ( Q-Marker ) prediction

关键词:  血竭  化学成分  药理作用  质量标志物

Key words:  draconis sanguis  chemical composition  pharmacological effects  Q-markers

摘要:

摘要：血竭以其活血定痛、化瘀止血和生肌敛疮的功效而被广泛使用。文章深入探讨了血竭的药理作用以及化学成分，包括黄酮类、挥发油类、有机酸类、苯丙素类等，这些成分是血竭药理作用的物质基础。这些发现为血竭在临床上的广泛应用提供了科学依据。文中对血竭的临床应用进行了全面的综述，包括其在治疗疮疡不敛、跌打损伤、外伤出血等方面的应用。鉴于血竭现有质量评价的不足，文中进一步探讨了血竭的质量标志物（Q-marker）的概念，并从植物近缘及其成分特有性、传统药性相关性、传统药效相关性、化学成分可测性四个方面进行了预测，以期为完善血竭的质量评价体系提供参考。

Abstract:

ABSTRACT : Draconis Sanguis is widely used for its effects of promoting blood circulation and relieving pain, removing blood stasis and hemostasis, and promoting muscle and astringing sores. In this paper, the pharmacological effects and chemical components of Draconis Sanguis were discussed in depth, including flavonoids, volatile oils, organic acids, phenylpropanoids, etc. These components are the material basis of the pharmacological effects of Draconis Sanguis. These findings provide a scientific basis for the wide clinical application of Draconis Sanguis. In this paper, the clinical application of Draconis Sanguis was comprehensively reviewed, including its application in the treatment of ulcers, injuries, traumatic bleeding and so on. In view of the shortcomings of the existing quality evaluation of Draconis Sanguis, this paper further discusses the concept of quality marker ( Q-marker ) of Draconis Sanguis, and predicts the quality of Draconis Sanguis from four aspects : plant relatives and their component specificity, traditional drug property correlation, traditional drug efficacy correlation and chemical composition measurability, in order to provide reference for improving the quality evaluation system of Draconis Sanguis.