线粒体能量代谢在动脉粥样硬化作用中的研究进展

Research progress of mitochondrial energy metabolism in atherosclerosis

关键词:  线粒体、能量代谢、动脉粥样硬化、发病机制

Key words:  Mitochondria, Energy Metabolism, Atherosclerosis, Pathogenesis

摘要:

动脉粥样硬化（Atherosclerosis）是全球范围内导致心血管疾病的主要病因之一，其发病机制复杂且多样。近年来，线粒体能量代谢在动脉粥样硬化中的作用受到了广泛关注。线粒体是细胞的能量中心，通过氧化磷酸化生成三磷酸腺苷（ATP），维持细胞的正常功能。此外，线粒体还在调节细胞内钙稳态、产生活性氧（ROS）以及细胞凋亡中发挥关键作用。本文综述了近年来关于线粒体能量代谢在动脉粥样硬化中的研究进展，旨在揭示其在病理机制中的重要作用，并为未来的研究和治疗提供新的思路。

Abstract:

Atherosclerosis is one of the leading causes of cardiovascular diseases worldwide, with a complex and multifaceted pathogenesis. In recent years, the role of mitochondrial energy metabolism in atherosclerosis has garnered significant attention. Mitochondria serve as the cellular powerhouses, generating adenosine triphosphate (ATP) through oxidative phosphorylation to maintain normal cellular functions. Additionally, mitochondria play a crucial role in regulating intracellular calcium homeostasis, producing reactive oxygen species (ROS), and mediating apoptosis. This review summarizes recent advancements in the study of mitochondrial energy metabolism in atherosclerosis, aiming to elucidate its critical role in the pathophysiology of the disease and to provide new insights for future research and therapeutic strategies.