类器官/器官芯片技术在生理药动学建模中的创新应用

Innovative Applications of Organoids/Organ-on-a-Chip Technologies in Physiologically Based Pharmacokinetic Modeling

关键词:  类器官  器官芯片  生理药动学模型  体内相关性

Key words:  organoids  organ-on-a-chip  physiologically based pharmacokinetic model  in vivo relevance

摘要:

传统细胞模型和动物模型在模拟人体组织的复杂性和相关性上有一定的局限,使得临床转化与生理药动学模型预测准确性受限。类器官和器官芯片作为药物研究的新工具,更贴近体内生理过程,可模拟机体复杂的机械环境和生理反应。本文综述了类器官和器官芯片在生理药动学建模方面的研究进展,展示了这种结合如何有潜力提高临床前研究到临床阶段的转化效率和预测准确性,从而为药物开发和评估带来新的视角。

Abstract:

Two-dimensional cells and animals have certain limitations in simulating the complexity and relevance of human tissues, which restrict the accuracy of clinical translation and physiologically based pharmacokinetic model predictions. Organoids and organ-on-a-chip technologies, as new tools in drug research, more closely mimic in vivo physiological processes and can simulate the complex mechanical environments and physiological responses of the body. This article reviews the research progress of organoids and organ-on-a-chip in physiologically based pharmacokinetic modeling, demonstrating how this combination has the potential to improve the translational efficiency from preclinical research to the clinical phase and enhance predictive accuracy, thereby offering new perspectives for drug development and assessment.