| 引用本文: | 丁兆奇,张金朋,崔新元,冀钰洁,孙国浩,张一春,袁泽洋,王一冰,王心怡,刘媛媛.五味子木脂素16种成分的大鼠血浆药动学研究[J].中国现代应用药学,2026,43(1):65-75. |
| Ding Zhaoqi,Zhang Jinpeng,Cui Xinyuan,Ji Yujie,Sun Guohao,Zhang Yichun,Yuan Zeyang,Wang Yibing,Wang Xinyi,Liu Yuanyuan.In vivo Pharmacokinetics of 16 effective components of Schisandra lignans in rat plasma[J].Chin J Mod Appl Pharm(中国现代应用药学),2026,43(1):65-75. |
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| 五味子木脂素16种成分的大鼠血浆药动学研究 |
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丁兆奇1, 张金朋2, 崔新元1, 冀钰洁1, 孙国浩1, 张一春1, 袁泽洋1, 王一冰1, 王心怡1, 刘媛媛1
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1.山东第一医科大学（山东省医学科学院）药学院（药物研究所）;2.黔西南州妇幼保健院（儿童医院）
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| 摘要: |
| 目的 利用超高效液相色谱-三重四级杆质谱（UPLC-TQ-MS）研究五味子木脂素中五味子醇甲、戈米辛D、戈米辛J等16种成分在正常大鼠血浆中的体内药动学。方法 SD大鼠灌胃给予五味子木脂素纯化物的0.5%羧甲基纤维素钠（CMC-Na）混悬液（0.01 mL·g-1），连续给药5天，并于最后一次给药后0、0.08、0.25、0.5、1、1.5、2、4、6、8、10、12、24、30、36、48、72 h眼静脉丛取血，利用UPLC-TQ-MS法测定血浆中各成分浓度，并计算主要药动学参数。结果 除戈米辛G在大鼠血浆中的响应低于定量下限外，其余15个五味子木脂素成分均能被吸收进入血液，且大部分木脂素药时曲线存在双峰现象，可部分延长其作用时间。结论 综上所述，本研究进一步完善了木脂素成分在大鼠体内的药动学过程，对于开展木脂素有效成分的相关研究及临床应用提供了有益参考。 |
| 关键词: 五味子木脂素 有效成分 体内药动学 UPLC-TQ-MS |
| DOI： |
| 分类号:R284.1；R917.101 |
| 基金项目:国家青年自然科学基金项目（82204749）；山东省青年自然科学基金项目（ZR2021QH092）；山东省大学生创新创业训练计划项目（S202410439022）；2024年度山东第一医科大学教育教学改革研究项目（XM2024003） |
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| In vivo Pharmacokinetics of 16 effective components of Schisandra lignans in rat plasma |
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Ding Zhaoqi1, Zhang Jinpeng2, Cui Xinyuan1, Ji Yujie1, Sun Guohao1, Zhang Yichun1, Yuan Zeyang1, Wang Yibing1, Wang Xinyi1, Liu Yuanyuan1
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1.School of Pharmaceutical Sciences ＆ Institute of Materia Medica, Shandong First Medical University ＆ Shandong Academy of Medical Sciences;2.Qianxinan Prefecture Maternal and Child Health Hospital
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| Abstract: |
| ABSTRACT: OBJECTIVE To study the in vivo pharmacokinetics of 16 components including Schisandrol A, Gomisin D, and Gomisin J in the Schisandra lignans in rat plasma using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry (UPLC-TQ-MS). METHODS Eight rats given intragastric administration of the 0.5% carboxymethyl cellulose sodium (CMC-Na) suspension (0.01 mL·g-1) of purified Schisandra lignans, after which blood collection was performed at 0, 0. 08, 0. 25, 0. 5, 0. 75, 1, 1. 5, 2, 4, 6, 8, 12, 24, 48 h, UPLC-TQ -MS was adopted in the plasma concentration determination of various active constituents, and main pharmacokinetic parameters were calculated. RESULTS Among the 16 bioactive constituents of Schisandra lignans, 15 are capable of being absorbed into the bloodstream, while Gomisin G stands out as it remains undetected in rat plasma, falling below the quantifiable threshold. Furthermore, most of the Schisandra lignans have a bimodal drug-time curves, which can partially prolong the duration of action of the lignans. CONCLUSION In conclusion, the present study further improved the pharmacokinetic process of Schisandra lignans in rats, and provided a useful reference for carrying out the research related to the active ingredients of lignans and their clinical applications. |
| Key words: Schisandra lignans effective component in vivo Pharmacokinetic UPLC-TQ-MS |
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