铋基纳米材料在声动力治疗癌症中的研究进展

Research Progress of Bismuth-Based Nanomaterials in Sonodynamic Therapy for Cancer

关键词:  声动力疗法  铋基纳米材料  癌症

Key words:  Sonodynamic therapy  Bismuth-based nanomaterials  Cancer

摘要:

声动力疗法是一种前沿治疗技术,通过外部超声激发声敏感因子(即声敏剂)产生活性氧分子,从而对癌细胞造成不可逆转的氧化应激损伤以对抗癌症,具有非侵入性、低皮肤刺激性及优越的组织穿透性。近年来,随着纳米技术的迅猛发展,铋基纳米材料因其良好的生物相容性和突出的理化特性,被作为一种新型声敏剂广泛用于声动力治疗癌症领域。本文全面阐述了铋基纳米材料在声动力抗癌疗法中的核心作用机制,系统回顾了其在癌症治疗领域的最新研究进展,并深入探讨了这些材料的生物安全性问题。旨在为未来铋基纳米材料在临床应用上的进一步探索与实践提供坚实的理论基础与参考指南。

Abstract:

Sonodynamic therapy represents a cutting-edge treatment technique, and it leverages external ultrasound to activate sonosensitizers, generating reactive oxygen species to efficiently eliminate cancer cells. This approach boasts non-invasiveness, low skin sensitivity, and exceptional tissue penetration. In recent years, with the rapid advancement of nanotechnology, bismuth-based nanomaterials have been widely employed as a novel type of sonosensitizer in sonodynamic therapy for cancer, owing to their excellent biocompatibility and outstanding physicochemical properties. This paper comprehensively and exhaustively elucidates the core mechanisms underlying the role of bismuth-based nanomaterials in sonodynamic cancer therapy. It systematically reviews the latest research progress achieved in the field of cancer treatment using these materials and delves into their biosafety issues. The aim is to provide a solid theoretical foundation and reference guide for further exploration and practice of bismuth-based nanomaterials in clinical applications in the future.