浙江省头孢他啶-阿维巴坦临床用药指引

Clinical Guidelines for the Use of Ceftazidime-Avibactam in Zhejiang Province

关键词:  头孢他啶-阿维巴坦  合理用药  用药指引  药事管理

Key words:  ceftazidime-avibactam  rational drug use  clinical guidelines  pharmaceutical management

摘要:

目的：规范头孢他啶-阿维巴坦在多重耐药革兰阴性菌感染治疗中的临床合理应用，提供科学指导。 方法：浙江省医院药事管理质控中心、浙江省药学感染药学专业委员会、浙江省药学会微生物耐药与控制专业委员会以及浙江医学会细菌感染和耐药防治专业委员会联合组织了浙江省临床药学、感染病学和微生物学领域的专家团队。基于循证医学证据和专家意见，经过多轮专家讨论，制定了头孢他啶-阿维巴坦的临床用药指引。 结果：该指引共包含13个临床问题和28条推荐意见，涵盖了头孢他啶-阿维巴坦的适应证、抗菌谱、用法用量、特殊人群使用、血药浓度监测及临床管理等内容。 结论：该指引为临床医生提供了科学的指导，有助于确保头孢他啶-阿维巴坦的合理使用，提高多重耐药革兰阴性菌感染的治疗效果。

Abstract:

Objective: To standardize the clinical rational use of ceftazidime-avibactam in the treatment of multidrug-resistant Gram-negative bacterial infections and provide scientific guidance. Methods: The Zhejiang Provincial Center for Hospital Pharmaceutical Quality Control, the Zhejiang Pharmaceutical Society's Committee on Infectious Diseases Pharmacy, the Zhejiang Pharmaceutical Society's Committee on Microbial Resistance and Control, and the Zhejiang Medical Association's Committee on Bacterial Infection and Resistance Prevention and Control jointly organized an expert team in the fields of clinical pharmacy, infectious diseases, and microbiology from Zhejiang Province. Based on evidence-based medical evidence and expert opinions, and after multiple rounds of expert discussions, a clinical medication guide for ceftazidime-avibactam was developed. Results: The guide includes 13 clinical questions and 28 recommendations, covering aspects such as indications, antimicrobial spectrum, dosage and administration, use in special populations, therapeutic drug monitoring, and clinical management of ceftazidime-avibactam. Conclusion: The guide provides scientific guidance for clinicians, helping to ensure the rational use of ceftazidime-avibactam and improve the treatment outcomes of multidrug-resistant Gram-negative bacterial infections.