| 引用本文: | 鲍悦,汪佳楠,刘小勤,吴鸳鸯,洪利娅.莫匹罗星软膏的流变学特性研究[J].中国现代应用药学,2025,42(21):63-62. |
| baoyue,wangjianan,liuxiaoqin,wuyuanyang,hongliya.Study on the Rheological Properties of Mupirocin Ointment[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(21):63-62. |
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| 摘要: |
| 目的 研究莫匹罗星软膏的流变学特性，剖析流变学特性与处方组成及比例间的内在联系。方法 使用赛默飞 HAAKE MARS40流变仪对市售莫匹罗星软膏进行流动曲线、振幅扫描、频率扫描和触变恢复测定；并引入体外释放实验，进一步验证处方组成及比例对流变特性的影响；通过Peason相关分析研究流变学特性与处方组成及比例的相关性。结果 以P20不锈钢平板为夹具，在温度为25±0.1℃条件下测定莫匹罗星软膏的流动曲线、振幅扫描、频率扫描和触变恢复，方法精密度良好。经过测定，莫匹罗星软膏中PEG400含量越高，三维网络结构的强度越低，软膏的黏度越低，流动性越好，体外释放速率更高。结论 莫匹罗星软膏中处方组成及比例与其流变特性具有一定的相关性，不同的处方组成及比例通过改变流变特性，从而对药物释放产生影响。 |
| 关键词: 莫匹罗星软膏 流变学 PEG分子量 体外释放 |
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| Study on the Rheological Properties of Mupirocin Ointment |
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baoyue, wangjianan, liuxiaoqin, wuyuanyang, hongliya
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Zhejiang Institute for Food and Drug Control
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| Abstract: |
| OBJECTIVE To investigate the rheological properties of Mupirocin Ointment and expound the correlation between the rheological properties and the composition and proportion of the prescription. METHODS The flow curve, amplitude scanning, frequency scanning and thixotropic recovery of commercially available Mupirocin Ointment were determined by using the Thermo Fisher HAAKE MARS40 rheometer. In addition, in vitro release experiments were introduced to further verify the influence of the composition and proportion of the prescription on the rheological properties. Pearson correlation analysis was used to clarify the correlation between the rheological properties and the composition and proportion of the prescription. RESULTS Using a P20 stainless steel flat plate as the fixture, the flow curves, amplitude scanning, frequency scanning and thixotropic recovery of Mupirocin Ointment were determined at a temperature of 25 ± 0.1 °C, and the method showed good precision. Through the determination, the higher the content of PEG400 in Mupirocin Ointment, the lower the strength of the three-dimensional network structure, the lower the viscosity of the ointment, the better the fluidity, and the higher the in vitro release rate. CONCLUSION There is a certain correlation between the composition and proportion of the prescription of Mupirocin Ointment and its rheological properties. Different composition and proportion of the prescription affect the drug release by changing the rheological properties. |
| Key words: mupirocin ointment rheology molecular weight of PEG in vitro release |
