中药调控TGF-β1/Smads信号通路治疗术后腹腔粘连的研究进展

Progress of Chinese Medicine based on TGF-β1/Smads Signaling Pathway in Regulating Postoperative Peritoneal Adhesion: A review

关键词:  术后腹腔粘连  中医药  肠粘连  TGF-β1/Smads信号通路  研究进展  

Key words:  Postoperative peritoneal adhesion  Traditional Chinese medicine  Intestinal adhesion  TGF-β1/Smads signaling pathway  Research progress

摘要:

术后腹腔粘连（Postoperative abdominal adhesion,PAA）是腹部手术后一种常见的并发症，主要表现为腹膜、脏器与腹壁之间出现异常连接。这种异常连接可能导致慢性腹痛、便秘腹泻、肠梗阻甚至危及患者生命。目前主要的外科治疗手段是腹腔粘连松解术，不仅对患者的生活质量产生了极大的负面影响，还对患者心理健康造成了严重的冲击。近年来，中医药以其见效显著、低价和副作用小受到广大临床工作者和患者的高度认可。随着中医长期以来的“辩证论治”、“治未病”理论临床应用，越来越多人认识到中医药在以防代治方面的独特优势。近年来，转化生长因子β1(transforming growth factor-β1, TGF-β1)/Smads蛋白家族因其在诱导细胞凋亡、合成与重塑ECM、免疫调节、组织修复与血管再生中的核心作用，成为PAA防治的重要靶点。本文系统综述了TGF-β1/Smads信号通路在防治PAA中的作用机制，并从中药单体、中药复方及相关防治中药等多个方面进行了总结和归纳，旨在为PAA的机制研究与临床干预提供理论依据，为后续围绕PAA的实验研究和临床应用提供系统的参考价值。

Abstract:

Abstract: Postoperative abdominal adhesion (PAA) is a common complication after abdominal surgery, mainly characterized by abnormal connections between the peritoneum, organs and the abdominal wall. Such abnormal connections may lead to chronic abdominal pain, constipation and diarrhea, intestinal obstruction, and even threaten the patient's life. Currently, the main surgical treatment method is adhesion lysis, which not only has a significant negative impact on the patient's quality of life, but also causes serious psychological stress. In recent years, traditional Chinese medicine (TCM) has been highly recognized by clinical workers and patients for its significant efficacy, low cost and few side effects. With the clinical application of the long-standing TCM theories of "syndrome differentiation and treatment" and "preventing disease before it occurs", more and more people have recognized the unique advantages of TCM in prevention. In recent years, the transforming growth factor-β1 (TGF-β1)/Smads protein family has become an important target for the prevention and treatment of PAA due to its core role in inducing cell apoptosis, synthesizing and remodeling the extracellular matrix (ECM), immune regulation, tissue repair and angiogenesis. This article systematically reviews the mechanism of the TGF-β1/Smads signaling pathway in the prevention and treatment of PAA, and summarizes and generalizes from multiple aspects such as single extracts of traditional Chinese medicine, traditional Chinese medicine formulas and related preventive and therapeutic traditional Chinese medicines, aiming to provide a theoretical basis for the mechanism research and clinical intervention of PAA, and to offer systematic reference value for subsequent experimental research and clinical application around PAA.