| 引用本文: | 邹小鹏,朋小军,田光宗,胡静,尹健.壳寡糖四糖的化学合成研究[J].中国现代应用药学,2025,42(19):109-118. |
| Zou Xiaopeng,Peng Xiaojun,Tian Guangzong,Hu Jing,Yin Jian.Study on the chemical synthesis of the chitosan tetrasaccharide[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(19):109-118. |
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| 摘要: |
| 目的 开发一种高效合成壳寡糖四糖的化学方法，为壳寡糖结构与功能之间的关系研究提供物质基础。方法 以D-葡萄糖为起始原料，通过合理的设计正交保护策略，优化合成路线，提高壳寡糖四糖的合成效率。结果 成功建立了一条高效的合成路线，仅需12步反应即可完成关键糖基供体与受体的制备，并最终实现壳寡糖四糖的精准合成。结论 本研究开发了一种高效的壳寡糖四糖合成策略，具有保护基与糖砌块种类少、合成步骤简洁等特点，展现出良好的规模化制备应用前景。 |
| 关键词: 壳寡糖四糖 化学合成 正交保护 糖基化反应 |
| DOI： |
| 分类号:R284.1；R917.101 |
| 基金项目:国家自然科学基金 |
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| Study on the chemical synthesis of the chitosan tetrasaccharide |
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Zou Xiaopeng,Peng Xiaojun,Tian Guangzong,Hu Jing,Yin Jian
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1.Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University;2.Wuxi School of Medicine, Jiangnan University;3.Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology School of Life Sciences and Health Engineering, Jiangnan University
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| Abstract: |
| ABSTRACT: OBJECTIVE This study aims to develop an efficient chemical method for synthesizing chitosan tetrasaccharide, thereby providing a material basis for investigating the structure-activity relationship of chitooligosaccharides. METHODS Utilizing D-glucose as the starting material, we have rationally designed orthogonal protection strategies and optimized the synthetic route to enhance the synthesis efficiency of chitosan tetrasaccharide. RESULTS A highly efficient synthetic route was successfully established, requiring only 12 steps to complete the preparation of key glycosyl donors and acceptors, achieving the precise synthesis of the target tetrasaccharide. CONCLUSION This study presents an efficient synthesis strategy for the synthesis of a chitosan tetrasaccharide, featuring a minimal use of protecting groups and building blocks, as well as streamlined synthetic steps, thereby demonstrating strong potential for scalable production. |
| Key words: chitosan tetrasaccharide chemical synthesis orthogonal protection glycosylation |
