基于辅料改性的菌粉流动性优化与吸湿性抑制研究

Optimisation of flowability and inhibition of hygroscopicity of bacterial powder based on modification of excipients

关键词:  粉体学特性  辅料  超微粉碎  吸湿性

Key words:  powder characteristics  excipients  superfine pulverization  moisture absorption

摘要:

目的 探究不同辅料种类用量、不同制备方式对发酵虫草菌粉粉体流动性、吸湿性的影响。方法 从10种辅料中筛选3种,通过超微复合粒子和物理混合两种方式,考察与发酵虫草菌粉最优混合时间、比例,比较其对流动性与吸湿性改善效果,同时建立吸湿性方程的拟合模型。结果 根据粉体特性、流变性以及吸湿特性综合分析,筛选出3种辅料为疏水性二氧化硅、交联聚维酮、糊精。接触角得出的最佳工艺参数:辅料-添加比例-粉碎时长为SiO2-3%-3min、交联聚维酮-1%-1min、糊精-1%-1min,添加辅料进行物理混合后阻湿性、流动性良好,二氧化硅效果最佳。结论 添加辅料是发酵虫草菌粉改善流动性的常用方式,疏水性二氧化硅各方面的改善效果最优,其次,物理混合操作简单,使粉体更易流动,同时双指数模型和威布尔模型两种吸湿动力学模型为对发酵虫草菌粉-辅料有较高的拟合度,提供了较好的理论依据。

Abstract:

Objective To explore the effects of different types and amounts of excipients and different preparation methods on the fluidity and hygroscopicity of fermented Cordyceps powder. METHODS Three kinds of excipients were selected from 10 kinds of excipients. The optimal mixing time and proportion of fermented Cordyceps powder were investigated by means of ultrafine composite particles and physical mixing. The improvement effect of fluidity and hygroscopicity was compared, and the fitting model of hygroscopicity equation was established. RESULTS According to the comprehensive analysis of powder characteristics, rheological properties and moisture absorption characteristics, three excipients were selected as hydrophobic silica, crosslinked povidone and dextrin. The optimum process parameters obtained by the contact angle are as follows : the excipient-addition ratio-grinding time is SiO2-3 % -3min, cross-linked povidone-1 % -1min, dextrin-1 % -1min.After adding excipients for physical mixing, the moisture resistance and fluidity are good, and the silica effect is the best. CONCLUSION Adding excipients is a common way to improve the fluidity of fermented Cordyceps powder. Hydrophobic silica has the best improvement effect in all aspects. Secondly, the physical mixing operation is simple, which makes the powder easier to flow. At the same time, the two hygroscopic kinetic models of double exponential model and Weibull model provide a good theoretical basis for the high fitting degree of fermented Cordyceps powder-excipients.