中枢神经系统疾病铁死亡纳米药物递释系统的研究进展

Research Progress on Ferroptosis-Related Nanodrug Delivery Systems for Central Nervous System Diseases

关键词:  铁死亡  中枢神经系统疾病  纳米药物递释系统  诊疗一体化

Key words:  ferroptosis  central nervous system diseases  nanoparticulate drug delivery system  theranostics

摘要:

铁死亡与中枢神经系统(CNS)疾病的病理机制密切相关,但由于血脑屏障(BBB)等生理结构及神经系统高度敏感性,其临床治疗药物转化面临显著挑战。本综述围绕铁死亡的分子调控机制与临床治疗策略,系统总结了基于铁死亡机制的CNS疾病药物治疗研究进展,重点从铁代谢、脂质过氧化和抗氧化系统三大通路探讨了纳米药物递释系统的应用现状。此外,文章还介绍了铁死亡诊疗一体化平台的最新成果,并对该领域面临的挑战与发展前景进行展望,以期为CNS疾病的临床诊疗提供新思路。

Abstract:

Ferroptosis is intricately associated with the pathological mechanisms of central nervous system (CNS) diseases. However, the translational development of therapeutic agents faces significant challenges due to physiological structures such as the blood-brain barrier (BBB) and the high susceptibility of the neural environment. This review summarizes recent advances in pharmacotherapeutic strategies targeting ferroptosis for CNS diseases, with a focus on the molecular regulatory mechanisms and clinical treatment approaches. Specifically, it discusses the application of nanodrug delivery systems modulating three core pathways: iron metabolism, lipid peroxidation, and the antioxidant system. Furthermore, the review highlights recent progress in integrated ferroptosis theranostic platforms and provides perspectives on current challenges and future directions, aiming to offer new insights for clinical diagnosis and treatment of CNS diseases.