| 引用本文: | 刘淑兰,周艺林,周莉莉,邹蔓姝,夏新华.外泌体作为siRNA递送载体的研究进展[J].中国现代应用药学,2021,38(7):880-886. |
| LIU Shulan,ZHOU Yilin,ZHOU Lili,ZOU Manshu,XIA Xinhua.Research Progress on Exosomes as siRNA Delivery Carriers[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(7):880-886. |
|
| 摘要: |
| 小干扰RNA （small interference RNA，siRNA）可以选择性靶向和下调致病基因，在治疗人类疾病，特别是恶性肿瘤方面具有很大前景。为了增强siRNA递送系统的靶向性和治疗效果，许多载体已被广泛研究。外泌体存在于机体内源性系统，具有较高的生物相容性、低免疫原性、主动靶向性等优点，是一种很有潜力的siRNA递送载体。本文对外泌体siRNA递送系统的优势与不足、siRNA载入外泌体的方式、外泌体介导siRNA靶向递送及应用等进行了综述，旨在为外泌体作为一种新型靶向载体用于siRNA递送系统的研究提供参考。 |
| 关键词: 外泌体 siRNA 递送载体 转染 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.07.020 |
| 分类号:R945 |
| 基金项目:国家自然科学基金项目（81573621）；湖南省科技计划项目（2017SK2122）；湖南省教育厅研究生教育创新工程和专业能力提升工程项目（CX20200756） |
|
| Research Progress on Exosomes as siRNA Delivery Carriers |
|
LIU Shulan, ZHOU Yilin, ZHOU Lili, ZOU Manshu, XIA Xinhua
|
|
Hunan University of Chinese Medicine, Changsha 410208, China
|
| Abstract: |
| siRNA shows great prospect in the treatment of human diseases, especially malignant tumors with its targeted selectivity and pathogenic gene down-regulation. In order to enhance the targeting and therapeutic effectiveness of siRNA delivery systems, many vectors have been extensively studied. Exosomes is a promising siRNA delivery carrier which exists in the endogenous system of the body, with advantages of high biocompatibility, low immunogenicity and active targeting, etc. In this paper, the advantages and disadvantages of the exosome siRNA delivery system, the way siRNA is loaded into exosomes, and the exosome-mediated targeted delivery of siRNA and its application are reviewed, aiming to provide reference for the study of exosomes as a new targeting carrier for siRNA delivery system. |
| Key words: exosomes siRNA delivery carriers transfection |
