| 引用本文: | 边阳萍,刘建辉.脂源性外泌体与肥胖诱导的代谢性炎症研究进展[J].中国现代应用药学,2021,38(8):1008-1011. |
| BIAN Yangping,LIU Jianhui.Research Progress on Lipid-derived Exosomes and Obesity-induced Metabolic Inflammation[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(8):1008-1011. |
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| 摘要: |
| 越来越多的研究结果显示，肥胖引起的代谢性炎症是导致胰岛素抵抗和一系列并发症的主要原因。脂肪组织作为代谢性炎症启动和发生的主要场所，其分泌的外泌体不仅是脂肪组织与其他组织、器官间通信的重要媒介，也是机体代谢性炎症的重要调节者。本文在介绍脂源性外泌体的成分及生物学功能的基础上，重点综述了脂源性外泌体在肥胖引起的代谢性炎症发生、发展中的作用及具体的作用机制。 |
| 关键词: 外泌体 代谢性炎症 肥胖 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.08.019 |
| 分类号:R966 |
| 基金项目:重庆市基础科学与前沿技术研究重点项目(cstc2017jcyjBX0077) |
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| Research Progress on Lipid-derived Exosomes and Obesity-induced Metabolic Inflammation |
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BIAN Yangping, LIU Jianhui
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Chongqing Key Lab of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China
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| Abstract: |
| The increasing studies have shown that metabolic inflammation caused by obesity is the main cause of insulin resistance and a series of complications. Adipose tissue is the main place for the initiation and occurrence of metaflammation, and the exosomes secreted by adipose tissue is not only an important medium for communication between adipose and other tissues and organs, but also an significant regulator of metaflammation. This paper introduced the composition and biological function of exosomes secreted from adipose tissue, and especially to summary the role and mechanism of these exosomes in the occurrence and development of metaflammation caused by obesity. |
| Key words: exosomes metaflammation obesity |
