基于Granada-Ⅱ分类法对住院患者质子泵抑制剂注射剂药物相关问题的调查分析

Research and Analysis of Proton Pump Inhibitors Injection Drug-Related Problems in Inpatients Based on Granada-II Classification

关键词:  质子泵抑制剂|药物相关问题|适应证|合理用药

Key words:  proton pump inhibitors|drug-related issues|indications|rational use of drugs

摘要:

目的 识别质子泵抑制剂（proton pump inhibitors， PPIs）注射剂临床应用的药物相关问题（drug-related problems，DRPs），为PPIs注射剂的规范化应用提供参考。方法 收集和整理淮南朝阳医院2019年7月-12月使用PPIs注射剂的病例，采用国际通用的西班牙药物相关问题Granada-Ⅱ分类法对PPIs注射剂的DRPs进行识别和分析。结果 417份PPIs注射剂病例均发现了DRPs，累计947个DRPs，主要为DRP5（527个，55.65%），DRP2（321个，33.89%），DRP6（62个，6.55%），DRP4（37个，3.91%）。DRP5主要表现为存在配伍禁忌的药物接瓶未冲管、给药途径不合理等，DRP2表现为无适应证用药，DRP6表现为药物的不良相互作用、预防用药疗程过长等，DRP4表现为疗程过短。结论 针对PPIs注射剂临床应用存在的DRPs，临床药师要制订相应的用药规则，协助医院加强对PPIs注射剂的应用管理，提高合理用药水平，保障医疗安全。

Abstract:

OBJECTIVE To identify the drug-related problems(DRPs) in the clinical application of proton pump inhibitors(PPIs) injection, and to provide reference for the standardized application of PPIs injection. METHODS The cases of using PPIs injection in Huainan Chaoyang Hospital from July to December 2019 were collected and sorted out. The DRPs of PPIs injection was identified and analyzed by Granada-Ⅱ classification of drug related problems in Spain which was widely used in the world. RESULTS DRPs were found in 417 cases of PPIs injection, with a total of 947 DRPs. They were mainly 527 DRP5 accounting for 55.65%, 321 DRP2 accounting for 33.89%, 62 DRP6 accounting for 6.55% and 37 DRP4 accounting for 3.91%. The main manifestations of DRP5 were the drugs with taboos were not flushed and the route of administration was unreasonable and so on. DRP2 showed that there was no indication for the use of drugs. DRP6 was characterized by adverse drug interaction, long course of preventive medication and so on. DRP4 showed that the course of treatment was too short. CONCLUSION In view of the DRPs existing in the clinical application of PPIs injection, clinical pharmacists should formulate corresponding drug use rules to assist hospitals to strengthen the application management of PPIs injection, improve the level of rational drug use and ensure medical safety.