差示扫描量热法测定磺胺类化学对照品的纯度

Determination of the Purity of Sulfonamide Chemical Reference Materials by Differential Scanning Calorimetry

关键词:  差示扫描量热法  磺胺类  化学对照品

Key words:  differential scanning calorimetry  sulfonamides  chemical reference substances

摘要:

目的 采用差示扫描量热法(differential scanning calorimetry，DSC)测定磺胺类化学对照品纯度。方法 采用优化DSC实验参数，载气流速50 mL·min^-1，升温速率3 ℃·min^-1，称样量1.3~2.0 mg，对7种磺胺类化学对照品进行纯度分析。结果 DSC测得磺胺噻唑纯度为99.9%，磺胺甲二唑为99.9%，磺胺甲氧嗪为99.8%，磺胺嘧啶为99.8%，磺胺甲噁唑为99.9%，磺胺多辛为99.5%和磺胺二甲嘧啶为99.9%，其结果与质量平衡法测定结果基本一致。结论 DSC简便、快捷、无需标准物质，为磺胺类化学对照品纯度测定提供了新的检测方法。

Abstract:

OBJECTIVE To determine the purity of sulfonamide chemical reference substances by differential scanning calorimetry(DSC).METHODS The purity of 7 sulfonamide chemical reference substances was determined by optimizing DSC parameters, carrier gas flow rate was 50 mL·min^-1, heating rate was 3 ℃·min^-1 and weighing amount was 1.3-2.0 mg.RESULTS The purity determined by DSC were 99.9%(sulfathiazole), 99.9%(sulfamethizole), 99.8%(sulfamethoxypridazine), 99.8%(sulfadiazine), 99.9%(sulfamethoxazole), 99.7%(sulfadoxine), and 99.9%(sulfadimidine), respectively. The results of purity determination by DSC method were basically consistent with those by mass balance method.CONCLUSION DSC is a simple, rapid method, and does not need standard substance. It provides a new method for the purity determination of sulfonamide chemical reference substances.