1例妊娠期铜绿假单胞菌宫腔感染的病例分析与药学监护

Analysis and Pharmaceutical Care of A Case of Intra-amniotic Infection with Pseudomonas Aeruginosa During Pregnancy

关键词:  胎膜早破  宫腔感染  铜绿假单胞菌  注射用亚胺培南西司他丁钠  药学监护

Key words:  premature rupture of membranes  intra-amniotic infection  Pseudomonas aeruginosa  imipenem cilastatin  pharmaceutical care

摘要:

目的 通过对1例胎膜早破、宫腔铜绿假单胞菌感染患者的抗感染治疗分析，探讨抗铜绿假单胞菌治疗过程中宫颈局部治疗初始效果不佳的原因和应对策略。方法 临床药师参与患者药物治疗方案的调整，结合目前铜绿假单胞菌的耐药情况和患者自身情况，建议临床医师调整抗感染治疗方案。结果 患者改用注射用哌拉西林钠他唑巴坦钠治疗1周后，临床症状显著好转。结论 临床药师参与临床治疗，协助临床医师优化治疗方案，使患者用药更加安全、有效和合理。

Abstract:

OBJECTIVE To report a case of antibiotic therapy in a patient with premature rupture of membranes(PROM) and intra-amniotic infection(IAI) with Pseudomonas aeruginosa(PA), discussed the reason of the poor initial effect of the local cervical treatment and the strategy of treatment in PA antibiotic therapy. METHODS Clinical pharmacists participated in the adjustment of patients' drug treatment plan, considering the current resistance of PA and the patient's own situation, clinical pharmacists suggested physicians to adjust the strategy of drug treatment. RESULTS After piperacillin sodium/tazobactam was applied for a week, the symptoms of the patient were obviously improved. CONCLUSION Clinical pharmacists participate in the clinical treatment, provide a reasonable clinical treatment program with physicians, can make the medication more safe, effective and reasonable for patients.