| 引用本文: | 杨山景,封安杰,孙越,张丽,薄福民,李凌军.白芍总苷的药理作用及机制研究进展[J].中国现代应用药学,2021,38(13):1627-1633. |
| YANG Shanjing,FENG Anjie,SUN Yue,ZHANG Li,BO Fumin,LI Lingjun.Research Progress on Mechanism and Pharmacological Activities of Total Glucosides of Paeony[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(13):1627-1633. |
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| 摘要: |
| 白芍总苷（total glucosides of paeony，TGP）是中药白芍的提取物中的有效部位，主要包括芍药苷、芍药内酯苷、氧化芍药苷等成分。现代药理研究发现TGP不仅具有免疫调节、抗炎、肝保护等作用，还具有脑及神经保护、心血管保护、肾脏保护和抑制细胞增殖等多种作用，具有良好的应用发展前景。本文对TGP的药理作用和作用机制研究进行归纳总结，以期为TGP的进一步开发研究提供参考。 |
| 关键词: 白芍总苷 药理作用 机制 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.13.015 |
| 分类号:R285 |
| 基金项目:“重大新药创制”国家科技重大专项（2017ZX09301064008） |
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| Research Progress on Mechanism and Pharmacological Activities of Total Glucosides of Paeony |
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YANG Shanjing, FENG Anjie, SUN Yue, ZHANG Li, BO Fumin, LI Lingjun
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College of Pharmaceutical Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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| Abstract: |
| Total glucosides of paeony(TGP) is an effective extraction part of Paeoniae Radix Alba, mainly including paeoniflorin, albiflorin, oxypaeoniflora and other components. Modern pharmacological studies have found that TGP not only has the functions of immune regulation, anti-inflammatory and liver protection, but also has the functions of brain and nerve protection, cardiovascular protection, kidney protection and cell proliferation inhibition. It has a good prospect of application and development. The pharmacological effects and mechanism of TGP were summarized inthis paper, in order to provide reference for the further development of TGP. |
| Key words: total glucosides of paeony pharmacological effects mechanism research progress |
