载脂蛋白E基因多态性对中国人群华法林维持剂量影响的meta分析

Meta Analysis of the Effect of Apolipoprotein E Gene Polymorphism on the Maintenance Dose of Warfarin in Chinese Population

关键词:  华法林  载脂蛋白E  基因  系统评价  维持剂量

Key words:  warfarin  apolipoprotein E(APOE)  gene  systematic review  maintenance dose

摘要:

目的 系统评价载脂蛋白E （apolipoprotein E，APOE）基因多态性与中国人群华法林维持剂量的关系。方法 计算机检索PubMed、EMBase、Cochrane图书馆、CNKI和万方数据库，收集中国人群APOE基因多态性与华法林维持剂量关系的研究，提取资料并评价文献质量，采用RevMan 5.3统计软件进行meta分析。结果 共纳入11项研究，2 320例患者。Meta分析结果显示，APOE E2（E2/E2，E2/E3）基因型华法林维持剂量比APOE E3（E3/E3）基因型高30%，APOE E2（E2/E2，E2/E3）基因型华法林维持剂量比APOE E4（E3/E4，E4/E4）基因型高43%，差异均具有统计学意义，APOE rs7412 TT基因型所需华法林维持剂量明显低于CC及CT基因型（P<0.05）。结论 中国人群APOE E2（E2/E2，E2/E3）基因型所需华法林维持剂量显著增高，APOE rs7412 TT基因型所需华法林维持剂量明显降低。

Abstract:

OBJECTIVE To systematically evaluate the relationship between apolipoprotein E(APOE) gene polymorphism and warfarin maintenance dose in Chinese population. METHODS PubMed, EMBase, Cochrane Library, CNKI and Wanfang databases were searched by computer to collect studies about the relationship between APOE gene polymorphisms and warfarin maintenance dose in Chinese population. The data were extracted and the quality of literature were evaluated, and meta analysis was performed by using RevMan 5.3 statistical software. RESULTS A total of 11 studies, involving 2 320 patients were included. Meta analysis results showed that the maintenance dose of warfarin required by APOE E2(E2/E2, E2/E3) genotype was 30% higher than the APOE E3(E3/E3) genotype, and the maintenance dose of warfarin required by APOE E2(E2/E2, E2/E3) genotype was 43% higher than that of APOE E4(E3/E4, E4/E4) genotype, and the differences were statistically significant. The maintenance dose of warfarin for APOE rs7412 TT was significantly lower than that of CC and CT(P<0.05). CONCLUSION In Chinese population, the maintenance dose of warfarin required by APOE E2(E2/E2, E2/E3) genotype is significantly increased, and the maintenance dose of warfarin required by APOE rs7412 TT genotype is significantly decreased.