鸡嘴簕的化学成分分离和鉴定

Isolation and Identification of Chemical Compounds from Caesalpinia sinensis

关键词:  云实属  鸡嘴簕  caesaloside A  2β-ethoxyclovane-9α-ol

Key words:  Caesalpinia  Caesalpinia sinensis  caesaloside A  2β-ethoxyclovane-9α-ol

摘要:

目的 对鸡嘴簕枝叶的化学成分进行分离和鉴定。方法 利用硅胶柱色谱、Sephadex LH-20凝胶柱色谱等现代多种色谱技术进行分离纯化，利用核磁共振等波谱技术和文献对照的方法进行结构鉴定。结果从鸡嘴簕枝叶中分离鉴定了12个化合物，分别为caesaloside A （1），2β-ethoxyclovane-9α-ol （2），2β-methoxyclovan-9α-ol （3），8（17），13-ent-labdadien-15→ 16-lactone-19-oic acid （4），高根二醇（5），3-甲氧基槲皮素（6），槲皮素（7），芹菜素（8），木犀草素（9），3，5-二羟基-4-甲氧基苯甲酸乙酯（10），没食子酸乙酯（11）和没食子酸（12）。结论 化合物1 和2 为新化合物，其余10个化合物皆为首次报道从该植物中分离得到。

Abstract:

OBJECTIVE To isolate and identify the chemical constituents of twigs and leaves of Caesalpinia sinensis. METHODS Compounds were purified and separated through silica gel and Sephadex LH-20 gel column chromatography, and other modern chromatographic techniques. Their structures were identified on the basis of NMR spectral analysis and comparing with the data in the literatures. RESULTS Twelve compounds were obtained and identified from twigs and leaves of Caesalpinia sinensis, they were caesaloside A(1), 2β-thoxyclovane-9α-ol(2), 2β-methoxyclovan-9α-ol(3), 8(17),13-ent-labdadien-15→16-lactone-19-oic acid(4), erythrodiol(5), 5,7,3',4'-trahydroxy-3-methoxyflavone(6), quercetin(7), apigenin(8), luteolin(9), ethyl-3,5-dihydroxy-4-methoxybenzoate(10), ethyl gallate(11) and gallic acid(12), respectively. CONCLUSION Compounds 1 and 2 are new compounds, and the other 10 compounds were isolated from this plant and reported for the first time.