| 引用本文: | 陈悦,王琨,张凌琳.壳聚糖包覆脂质体递药系统的研究进展[J].中国现代应用药学,2021,38(10):1251-1256. |
| CHEN Yue,WANG Kun,ZHANG Linglin.Research Progress of Liposomes Coated with Chitosan for Drug Delivery[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(10):1251-1256. |
|
| 摘要: |
| 脂质体在药物传递方面被广泛研究，但因结构稳定性差等因素使其应用受到了限制。壳聚糖是一种阳离子多糖，具有良好的生物相容性、生物降解性以及生物黏附性，并且可经化学改性成为性能更佳的壳聚糖衍生物。近年来，壳聚糖及其衍生物包覆脂质体在载药方面的研究得到了越来越多学者的关注。壳聚糖或其衍生物修饰脂质体，可提高其稳定性、黏附渗透性、药物缓释能力以及细胞摄取能力，并可在特定应用情况下，赋予递药系统pH敏感性。本文就近年来壳聚糖及其衍生物包覆脂质体用于药物传递的医学应用进展作一综述。 |
| 关键词: 壳聚糖 壳聚糖衍生物 脂质体 药物传递 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.10.019 |
| 分类号:R94 |
| 基金项目:国家自然科学基金项目（81970931）；四川省青年科技创新研究团队项目（2020JDTD0014） |
|
| Research Progress of Liposomes Coated with Chitosan for Drug Delivery |
|
CHEN Yue, WANG Kun, ZHANG Linglin
|
|
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Demonstration Center for Experimental Stomatology Education, West China School of Stomatology, Sichuan University, Chengdu 610041, China
|
| Abstract: |
| Liposomes have been widely studied in drug delivery.However, the application of liposomes has been limited due to poor stability and other factors.Chitosan is a kind of cationic polysaccharide, which has excellent biocompatibility, biodegradability and bioadhesion, and can be chemically modified with better properties.In recent years, more attention has been paid for the study of liposomes coated with chitosan and its derivatives for drug delivery.Liposomes modified by chitosan or its derivatives can be improved in the aspect of their stability, adhesion, permeability, drug sustained release and cell uptake, and can be used to provide pH sensitivity on the drug delivery system under particular conditions.In this paper, research progress of the medical application of liposomes coated with chitosan and its derivatives in drug delivery system are reviewed. |
| Key words: chitosan chitosan derivatives liposomes drug delivery |
