姜黄素纳米颗粒在中枢神经系统疾病中的研究进展

Research Progress of Curcumin Nanoparticles in Central Nervous System Diseases

关键词:  姜黄素纳米颗粒  神经系统疾病  综述

Key words:  curcumin nanoparticles  nervous system diseases  review

摘要:

姜黄素是一种提取自姜黄的多酚类化合物，具有神经保护作用，可以通过血脑屏障，是治疗多种神经系统疾病候选的理想药物。在胶质瘤、脑血管病、癫痫、神经退行性疾病和创伤性脑损伤等神经系统疾病中的作用已受到广泛关注。然而，姜黄素因生物利用率低，导致应用受到限制。近年来，人们发现纳米颗粒可有效提高姜黄素生物利用率。众多前期临床试验中发现，纳米颗粒药物输送系统使姜黄素药理作用得到了良好的应用。因此，本文就姜黄素纳米颗粒对中枢神经系统各类疾病的作用及机制的最新研究进展进行综述，以期为姜黄素在神经系统的广泛应用提供参考。

Abstract:

Curcumin is a polyphenolic compound derived from Curcuma longa L.. It has a neuroprotective effect and can pass through the blood-brain barrier. It is an ideal candidate drug for the treatment of various neurological diseases. Its role in neurological diseases such as glioma, cerebrovascular disease, epilepsy, neurodegenerative diseases and traumatic brain injury has attracted widespread attention. However, curcumin is limited in its application due to its low bioavailability. In recent years, it has been discovered that nanoparticles can effectively improve the bioavailability of curcumin. Many pre-clinical trials found that the nanoparticle drug delivery system has made curcumin pharmacologically well applied. Therefore, this article reviews the latest research progress on the effects and mechanisms of curcumin nanoparticles on various diseases of the central nervous system, in order to provide a reference for the treatment of nervous system diseases.