| 引用本文: | 李青宴,黄艳华,沈磊.cGMP及其介导的信号通路在血小板聚集中的作用的研究进展[J].中国现代应用药学,2021,38(23):3045-3049. |
| LI Qingyan,HUANG Yanhua,SHEN Lei.Research Progress of the cGMP Role and Its Mediated Signaling Pathway in Platelet Aggregation[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(23):3045-3049. |
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| 摘要: |
| 血栓是缺血性心脑血管疾病的主要杀手，血小板聚集在血栓形成过程中发挥着重要的作用。抗血小板聚集在血栓性疾病的治疗中无可替代。cGMP对血小板功能的调节起到非常重要的作用，且主要通过eNOS-NO-cGMP-PKG通路进行调节。本综述主要阐明cGMP在血小板聚集中的作用和机制。 |
| 关键词: 血小板聚集 环磷酸鸟苷 内皮型一氧化氮合酶 一氧化氮 cGMP依赖的蛋白激酶G 信号通路 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.23.022 |
| 分类号:R966 |
| 基金项目:云南省科技厅地方本科高校基础研究项目（2018FH001-096） |
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| Research Progress of the cGMP Role and Its Mediated Signaling Pathway in Platelet Aggregation |
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LI Qingyan, HUANG Yanhua, SHEN Lei
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College of Pharmacy, Dali University, Dali 671000, China
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| Abstract: |
| Thrombosis is the main killer of ischemic cardiovascular and cerebrovascular diseases. Platelet aggregation plays an important role in the process of thrombosis. Anti-platelet aggregation is irreplaceable in the treatment of thrombotic diseases. cGMP plays a very important role in the regulation of platelet function; and its role is mainly through the eNOS-NO-cGMP-PKG pathway. This review mainly clarifies the effect and mechanism of cGMP on platelet aggregation. |
| Key words: platelet aggregation guanosine 3',5'-cyclic monophosphate(cGMP) endothelial nitric oxide synthase(eNOS) NO cGMP-dependent kinase(PKG) signaling pathway |
