中国药品不良反应热点主题可视化研究

Visualization Research of Hot Topics of Adverse Drug Reactions in China

关键词:  药品不良反应  文献计量学  合理用药  不良反应监测

Key words:  adverse drug reactions(ADR)  bibliometrics  rational administration of drug  ADR monitoring

摘要:

目的 利用文献计量分析方法探究国内核心期刊药品不良反应（adverse drug reaction，ADR）文献的研究热点、关键点、薄弱点、特殊点以及整体结构等，以期为ADR监测者和研究者把握本领域的研究热点与发展态势提供参考和依据。方法 收集国内核心期刊ADR文献，对关键词进行抽取和统计，利用聚类分析、社会网络分析等方法对高频关键词进行可视化表达。结果 经检索和筛选确定12 527篇文献作为样本，包括关键词50 576个。45个高频关键词被划分为7类，关键词网络密度为0.59。结论 中国核心期刊ADR文献形成了以“合理用药”“不良反应监测”等为核心的研究热点，“儿童”成为新兴的研究热点。“合理用药”是本领域的关键点，其在网络沟通中的“桥梁作用”最为明显。“过敏性休克”“儿童”“肝损害”等是本领域的特殊点。从整体来看，中国核心期刊ADR文献研究已基本成型，但核心主题内容过多且繁杂，尚未形成有一定深度且界限清晰的核心主题。

Abstract:

OBJECTIVE To provide reference and basis for adverse drug reactions(ADR) monitors and researchers to grasp the research hotspots and development trends in this field, this paper explores the research hotspots, key points, weaknesses, special points and overall structure of ADR literature in domestic core journals by bibliometric analysis. METHODS ADR literatures of domestic core journals were collected, keywords were extracted and counted, and high frequency keywords were visualized by cluster analysis and social network analysis. RESULTS After searching and screening, 12 527 articles were selected as samples, including 50 576 keywords. The 45 high-frequency keywords were classified into 7 categories with a keyword network density of 0.59. CONCLUSION "Rational administration of drug" and "ADR monitoring" are the hot spots of ADR literatures in core journals. "Children" has become an emerging research hotspot. "Rational administration of drug" is the key point, which has the most obvious "bridge function". "Anaphylactic shock" "children" and "liver damage" are the special points. On the whole, ADR literatures in core journals have been shaped fundamentally. However, the content of core theme is complicated and overloaded. The core theme with a certain depth and clear boundary has not been formed.