纳米氧化铈在肿瘤防治中的应用研究进展

Research Progress in the Application of Cerium Oxide Nanoparticles in Cancer Prevention and Treatment

关键词:  纳米氧化铈  肿瘤防治  抗氧化特性  肿瘤微环境

Key words:  cerium oxide nanoparticles  cancer prevention and treatment  anti-oxidant property  tumor microenvironment

摘要:

纳米氧化铈（cerium oxide nanoparticles，CNPs）因其显著的再生抗氧化特性，在生物医学领域受到广泛关注。CNPs可保护正常细胞，减轻氧化损伤，预防与活性氧水平失调相关的疾病发生，如肿瘤等。在肿瘤治疗中，CNPs表现出细胞毒性，并可通过调控肿瘤微环境来抑制肿瘤细胞的侵袭。CNPs同时可作为增敏剂和保护剂与放疗联合应用，以提高疗效，减轻不良反应。此外，CNPs还有作为药物载体的潜质，可用于靶向给药。本文综述了CNPs在肿瘤防治中的应用和相关机制，以期为今后CNPs的深入研究及临床应用提供借鉴。

Abstract:

Cerium oxide nanoparticles(CNPs) are widely investigated in biomedical field due to their potent regenerative anti-oxidant properties. CNPs can protect normal cells from oxidative damage to prevent the development of diseases that are related to the dysregulation of reactive oxygen species levels, such as cancer, et al. In cancer treatment, CNPs exhibit cytotoxicity, and can modulate tumor microenvironment to repress tumor invasion. In combination with radiotherapy, CNPs can be used as both radiosensitizers and radioprotective agents to enhance the efficacy of radiotherapy and reduce adverse reactions. In addition, CNPs are promising vectors in targeted drug delivery. This review summarizes the application of CNPs in cancer prevention and treatment and its correlated mechanisms, in order to provide useful information for further research and clinical application of CNPs.