| 引用本文: | 付红红,黄海明,林雯,赵峰,杨林杰,吕良.靶向STAT3小分子抑制剂在肝癌治疗中的研究进展[J].中国现代应用药学,2022,39(20):2669-2676. |
| FU Honghong,HUANG Haiming,LIN Wen,ZHAO Feng,YANG Linjie,LYU Liang.Research Progress of STAT3 Targeted Small Molecule Inhibitors in the Treatment of Hepatocellular Carcinoma[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(20):2669-2676. |
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| 摘要: |
| 肝细胞癌(hepatocellular carcinoma，HCC)是中国常见的高发癌症之一。信号转导和转录激活因子3(signal transducer and activator of transcription，STAT3)是一个重要的转录因子，大量证据表明，STAT3在肝癌的发生、发展、转移和免疫调控中起着关键作用，STAT3持续激活程度与HCC的预后呈负相关。因此，STAT3作为一种新的HCC治疗靶点受到关注。本文对STAT3在HCC中的研究进展及靶向治疗情况进行了总结。 |
| 关键词: STAT3 肝细胞癌 靶向治疗 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.20.015 |
| 分类号:R966 |
| 基金项目:广西自然科学基金项目(2018JJB140010) |
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| Research Progress of STAT3 Targeted Small Molecule Inhibitors in the Treatment of Hepatocellular Carcinoma |
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FU Honghong, HUANG Haiming, LIN Wen, ZHAO Feng, YANG Linjie, LYU Liang
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The People's Hospital of Liuzhou, Liuzhou 545000, China
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| Abstract: |
| Hepatocellular carcinoma(HCC) is one of the most common cancers in China. Signal transduction and activator of transcription 3(STAT3) is an important transcription factor and a large amount of evidence has shown that STAT3 plays a key role in the occurrence, development, metastasis and immune regulation of HCC. Overexpression and constitutive activation of STAT3 have been frequently found in HCC and associated with poor prognosis. Thus, STAT3 has be attracted attention as a novel therapeutic target in HCC. Here, this review summarized the research progress and targeted therapy of STAT3 in HCC. |
| Key words: STAT3 hepatocellular carcinoma targeted therapy |
