基于多指标综合评分法优选连葛消渴提取液喷雾干燥工艺

Optimization of Spray-drying Process for Liange Xiaoke Extract Based on the Multi-index Comprehensive Scoring Method

关键词:  连葛消渴提取液  喷雾干燥  出粉率  含水率  葛根素  盐酸小檗碱  多指标综合评分法

Key words:  Liange Xiaoke extract  spray drying  flour yield  moisture content  puerarin  berberine hydrochloride  multi-index comprehensive scoring method

摘要:

目的 利用多指标综合评分法优选连葛消渴提取液的喷雾干燥工艺条件。方法 以喷干粉的出粉率、含水率以及葛根素和盐酸小檗碱的含量为评价指标，通过单因素试验确定喷雾干燥的影响因素；结合单因素试验结果，选取提取液相对密度、进风口温度、进液速度以及辅料加入量为考察因素，采用正交试验法优选连葛消渴提取液的喷雾干燥工艺。结果 提取液相对密度、进风口温度、进液速度及辅料加入量对喷干粉的出粉率、含水量以及葛根素和盐酸小檗碱的含量均有影响，其中进风口温度和进液速度对评价指标影响显著。经过优化，最终优选出该处方喷雾干燥工艺：进风口温度160℃、提取液的密度为1.07 g·mL^–1、进液速度7.5 mL·min^–1、糊精加入量为5%。结论 该优选工艺稳定、合理、可行，可为连葛消渴方后期的工业化生产奠定基础。

Abstract:

OBJECTIVE To optimize spray drying conditions of Liange Xiaoke extract by multi-index comprehensive score method. METHODS With spray powder flour yield, moisture content, content of puerarin and berberine as indexes, factors affecting spray drying were investigated by single factor test. With composite score of flour yield, moisture content, content of puerarin and berberine hydrochloride, orthogonal test was used to optimize spray-drying process with feeding speed, inlet air temperature, the amount of adjuvant and relative density of extract as factors.RESULTS The flour yield, moisture content, content of puerarin and berberine in Liange Xiaoke extract was directly influenced by feeding speed, inlet air temperature, the amount of adjuvant and relative density. Among these four process parameters, the inlet air temperature and feeding speed had significant effects. The optimal conditions were determined as follows:inlet air temperature 160℃, relative density of extract 1.07 g·mL^-1, feeding speed 7.5 mL·min^-1, and the amount of adjuvant 5%. CONCLUSION The optimized spary-drying process is stable, reasonable and feasible, it can be used as reference for industrial production.