介孔分子筛MCM-41对阿司匹林缓释作用的研究

Effects of Mesoporous Molecular Sieve MCM-41 on the Sustained Release of Aspirin

关键词:  介孔分子筛MCM-41  阿司匹林  缓释作用

Key words:  mesoporous moleculr sieve MCM-41  aspirin  sustained release

摘要:

目的 研究介孔分子筛MCM-41对阿司匹林的缓释作用。方法 以正硅酸乙酯为硅源，CTAB为模板剂，于室温、酸性条件下合成介孔分子筛MCM-41。采用浸渍法将阿司匹林装载在MCM-41孔道中，考察分子筛对阿司匹林的最大载药量。利用XRD、氮吸附、红外光谱法对组装前后的分子筛进行表征，并研究组装于分子筛上的阿司匹林在磷酸盐缓冲溶液中的释放情况。结果 MCM-41对阿司匹林的最大载药量达0.34 g·g^-1。组装体中的阿司匹林8 h和31 h时累积释放67.6%和90.2%。结论 介孔分子筛MCM-41对阿司匹林具有明显的缓释作用，介孔分子筛可作为一种新型药物缓释材料。

Abstract:

OBJECTIVE To study the aspirin sustained release based on the matrix of mesoporous molecular sieve MCM-41. METHODS Mesoporous molecular sieve MCM-41 was synthesized using TEOS as silicon source and CTAB as templates at room temperature and under acidic conditions. Aspirin was loaded into MCM-41 by immersion method. The obtained aspirin-MCM-41 assembly was characterized by IR, XRD and N₂-adsorption method. The maximum aspirin loading was determined. Finally the extended release of aspirin in assembly was demonstrated by in vitro release study. RESULTS The maximum aspirin loading into MCM-41 was 0.34 g·g^-1. 67.6% and 90.2% of aspirin was released from the assembly at 8 h and 31 h, respectively. CONCLUSION The result showed that the effect of slow release for aspirin was achieved by using the mesoporous molecular sieve MCM-41 as matrix, indicating a potential application of mesoporous molecular sieve in the sustained drug release system.