| 引用本文: | 王军，胡小丽，文伟河，杨雷雷，徐松，朱玉亮.氨基酸及短肽对天然药物的结构修饰[J].中国现代应用药学,2011,28(12):1095-1100. |
| WANG Jun, HU Xiaoli, WEN Weihe, YANG Leilei, XU Song, ZHU Yuliang.Chemical Modification of Natural Medicines by Amino Acids and Oligopeptides[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(12):1095-1100. |
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| 摘要: |
| 氨基酸、肽是生命活动的基础物质，有着特殊的生理功能。近来关于氨基酸和短肽用于天然药物结构修饰的研究报道越来越多。本文综述了氨基酸、短肽对一些溶解性差、不良反应大的天然药物如桦木酸、3-氧代齐墩果酸、喜树碱、长春碱、甘草酸、甘草次酸等化学结构的修饰及其药理活性的研究进展。 |
| 关键词: 氨基酸 短肽 天然药物 药理活性 结构修饰 |
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| Chemical Modification of Natural Medicines by Amino Acids and Oligopeptides |
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WANG Jun, HU Xiaoli, WEN Weihe, YANG Leilei, XU Song, ZHU Yuliang1,2
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1.College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;2.Jiangsu Police Institute, Nanjing 210012, China
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| Abstract: |
| Amino acids and peptids are the basic substance in life activities, and have special physiological functions. Recently, there have been more and more researches on the structural modification of natural medicines by amino acids or oligopeptides. In this paper, the natural medicines modified with amino acids or oligopeptides and their pharmacological activities were summarized. Topics covered included the natural medicines with poor solubility and high side effects, such as betulinic acid, 3-oxo-oleanolic acid, camptothecine, vincristine, glycyrrhizic acid, glycyrrhetinic acid, and so on. |
| Key words: amino acid oligopeptides natural medicine pharmacological activities structural modification |
