积雪草有效成分ADME的特性概述

赖俞瑾; 王胜浩<sup>*</sup>; 曾苏

引用本文:	赖俞瑾,王胜浩,曾苏.积雪草有效成分ADME的特性概述[J].中国现代应用药学,2013,30(7):805-808.
	LAI Yujin,WANG Shenghao ,ZENG Su.Review on the ADME Characterization of Bioactive Constituents in Centella Asiatica[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(7):805-808.

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积雪草有效成分ADME的特性概述
赖俞瑾^1,2, 王胜浩¹, 曾苏²
1.浙江省医学科学院药物所，杭州 310013;2.浙江大学药学院，杭州 310031

摘要:

积雪草酸及其衍生物是传统药用植物积雪草中含量较高并主要发挥活性的五环三萜类化合物，具有治疗皮肤损伤、抗癌、抗抑郁等多种药理活性，但口服生物利用度差。本研究通过查阅国内外相关文献，系统分析积雪草有效成分的吸收、分布、代谢和排泄(ADME)等药动学特点，探讨其口服生物利用度低的原因，并提出改善方法。

关键词: 积雪草有效成分药动学 ADME 生物利用度

DOI：

分类号:

基金项目:浙江省科技计划项目(2011F10048)；浙江省新世纪151人才工程(第二层次)；浙江省卫生高层次创新人才培养工程(2008)；浙江省医学重点学科群建设项目(XKQ-010-001)

Review on the ADME Characterization of Bioactive Constituents in Centella Asiatica

LAI Yujin^1,2, WANG Shenghao ¹, ZENG Su²

1.Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China

Abstract:

Asiatic acid and its derivatives are the most common triterpenoids in traditional popular medicinal herb Centella asiatica, and have been reported to possess various pharmacological activities such as anti-inflammatory, anticancer and antidepressant. However, their oral bioavailability is low. This article reviews recent advances in pharmacokinetics from the absorption, distribution, metabolism and excretion (ADME), to figure out the possible causes for their low oral bioavailability, and further to investigate the strategy for bioavailability improvement.

Key words: bioactive constituents of Centella asiatica pharmacokinetics ADME bioavailability