| 摘要: |
| 目的 建立高效液相色谱法测定阿苯达唑有关物质。方法 采用资生堂MGⅡ C18柱(250 mm×4.6 mm，5 μm)色谱柱；流动相：磷酸二氢铵溶液(1.67 mg·mL-1)-甲醇(40∶60)；检测波长：290 nm。 结果 样品中的杂质均能很好检出，各杂质与主峰之间的分离度良好，检测限为0.228 6 ng。结论 该方法简单快速，专属性强，结果准确，可用作阿苯达唑有关物质检查。 |
| 关键词: 阿苯达唑 有关物质 高效液相色谱法 |
| DOI： |
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| Determination of Related Substances in Albendazole by HPLC |
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湖北省食品药品监督检验研究院，武汉 430064
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Hubei Province Institute for Food and Drug Control, Wuhan 430064, China
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| Abstract: |
| OBJECTIVE To establish an HPLC method for determination of related substances in albendazole. METHODS PAK C18 HPLC packed column(MGⅡ, 250 mm×4.6 mm, 5 μm)was used, the mobile phase was ammonium dihydrogen phosphate-methanol(40∶60) and the determination wavelength was 290 nm. RESULTS Albendazole and related substances could be well isolated. The detection limit was 0.228 6 ng. CONCLUSION The method is simple, rapid, accurate and suitable for examinating the related substances of albendazole. |
| Key words: albendazole related substances HPLC |
