| 引用本文: | 杜焰，冯怡，徐德生，赵立杰.药物粉体压缩与结合特性研究进展[J].中国现代应用药学,2012,29(1):24-30. |
| DU Yan, FENG Yi, XU Desheng, ZHAO Lijie.Advances in Compression and Binding Characteristics of Pharmaceutical Powders[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(1):24-30. |
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| 摘要: |
| 目的 药物粉体物理性质与其压缩与结合特性对固体制剂的质量具有重大影响，对于药用粉体综合特性的理解目的在于改进制剂生产工艺。方法 本文从不同角度对有关药物粉体的压缩与结合特性的研究进行了综述，对于药物粉体的特性参数最新应用研究进行评价。国内外的研究在药用粉体的压缩过程中多使用数学模型，因此对相关数学模型进行了阐述。结果 对于药物粉体的压缩行为预测研究发现，药用粉体的机械特性一般可以用压合指数、硬度、抗张强度、杨氏模量等参数描述，从而指导生产。结论 掌握和理解粉体压缩与结合特性，是处方设计、产品研发以及解决生产中可能存在的实际问题的关键。 |
| 关键词: 药物粉体 压缩行为 特性参数 数学模型 |
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| 基金项目:上海市科委资助项目(09DZ2292000)；上海市自然基金资助项目(10ZR1430200)；上海市重点学科资助项目(J50302)；江西师范大学科技计划项目(201101) |
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| Advances in Compression and Binding Characteristics of Pharmaceutical Powders |
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DU Yan, FENG Yi, XU Desheng, ZHAO Lijie1,2
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1.Engineering Research Center of Modem Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2.Department of chemistry and chemical engineering, Jiangxi Normal University, Nanchang 330022, China
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| Abstract: |
| OBJECTIVE The physical properties of pharmaceutical powders and their compression and binding characteristics have a significant impact on quality of solid dosage. Understanding of comprehensive properties of pharmaceutical powders is helpful to improve production process of solid dosage. METHODS This article reviewed the research of compression and binding properties of pharmaceutical powder from different aspects. The new applied research on characteristic parameters of pharmaceutical powders was evaluated. So the relevant mathematical models were described in case that mathematical models were widely used in the compression process all over the world. RESULTS From the study on the prediction of pharmaceutical powders’ compression behavior, we could found that the mechanical properties of pharmaceutical powders could be described by binding index, hardness, tensile strength, Young's modulus and other parameters.They could be used to guide the production. CONCLUSION Understanding and grasping the comprehensive properties of powders was the key point during our formulation design, product development and solving practical production problems. |
| Key words: pharmaceutical powder compression behavior characteristic parameters mathematical models |
