槲皮素干预实验性慢性肾衰大鼠尿量与尿蛋白量动态变化

Effects of Quercetin on Quantitative Changes of Urine Volume and Uric Protein in Rats with Experimental Chronic Renal Failure

关键词:  槲皮素  慢性肾衰  尿量  尿蛋白量

Key words:  quercetin  chronic renal failure  urine volume  uric protein

摘要:

目的 观察槲皮素对实验性慢性肾衰大鼠尿量和尿蛋白量的影响。方法 给实验大鼠饲以含腺嘌呤饲料2月造成慢性肾衰；干预组经口给予槲皮素(100 mg·kg^-1·d^-1×42 d)治疗；每周测定实验大鼠24 h尿量和尿蛋白含量。结果 与肾衰对照组比较，槲皮素干预组大鼠肾脏指数、肾组织含水量、血清肌酐和尿素氮均显著降低；在整个观察过程中，干预组平均24 h尿量均显著增多，24 h尿蛋白量均显著减少。结论 槲皮素对大鼠实验性慢性肾衰具有显著防治作用。

Abstract:

OBJECTIVE The effects of quercetin on quantitative changes of urine and uric protein in rats with experimental chronic renal failure were studied. METHODS The rats in control and treated groups were fed with 0.75% adenine for 2 months to build up chronic renal failure modle; and the quercetin were administered orally (100 mg·kg^-1·d^-1) for 42 days to the rats in treated group. The quantities of 24 h urine and uric protein were determined weekly. RESULTS The renal indexes, water percentages of renal tissue, serum CREA and BUN levels in treated group decreased significantly when compared with those in control group (P＜0.001). The 24 h urine volume in treated group increased (P＜0.001), and 24 h uric protein decreased (P＜0.001) significantly than those in the control group. CONCLUSION Qercetin is effective in preventing and curing of chronic rend failure in rats.