| 摘要: |
| 目的 介绍传统剂型，新技术，新方法在黏膜给药系统上的研究进展。方法 综述了凝胶剂、喷雾剂、气雾剂、粉雾剂等传统剂型；微球、脂质体、纳米粒、乳剂、原位凝胶等新技术以及吸收促进剂、生物黏附剂、前体药物、酶抑制剂等方法在促进药物黏膜吸收方面的进展。结果 国内外对这些剂型、方法、技术等已经进行了广泛和深入的研究，取得了较大的进展。结论 黏膜给药系统已成为目前研究的热点，它是传统给药方式的补充，具有广阔的应用前景。同时，为了进一步促进黏膜给药系统的发展，对安全、低毒、有效的吸收促进剂和新型载药体系的开发仍将是今后研究的主要方向。 |
| 关键词: 黏膜 剂型 药物制剂 |
| DOI： |
| 分类号: |
| 基金项目:浙江省科技厅科技计划项目(2007C23003) |
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| Progress of Buccal Mucosa Drug Delivery System |
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1.浙江中医药大学，杭州 310053；2.浙江大学医学院附属邵逸夫医院，杭州 3100201,2
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1.Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China;2.SIR RUN RUN SHAW Hospital Affiliated with School of Medicine, Zhejiang University, Hangzhou 310020, China
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| Abstract: |
| OBJECTIVE To introduce the traditional formulations, new technologies, new methods applied in the mucosal drug delivery systems. METHODS Review gels, sprays, aerosols, dry powder inhalations, microspheres, liposomes, nanoparticles, emulsion, in situ gel, absorption enhancers, bioadhesive agents, prodrug, enzyme inhibitors in the promotion of mucosal drug delivery systems. RESULTS Formulations, methods and techniques have been extensively studied, and progresses have been made in recent years. COCLUSION Mucosal delivery system has become a research hotspot and it has broad application prospects to replace the traditional delivery system. Exploitation of low toxicity and effective absorption enhancers and new drug carrier systems will be the main aspects to develop the mucosal drug delivery system so as to promote the penetration of the drug. |
| Key words: mucosa formulation pharmaceutical preparation |
