牛乳铁蛋白对感染轮状病毒树鼩的治疗试验

Therapeutic Experiment of Bovine Lactoferrin on Rotavirus-infected Tree Shrew

关键词:  牛乳铁蛋白  轮状病毒  树鼩

Key words:  bovine lactoferrin  rotavirus-infected tree shrew  treatment

摘要:

目的 观察牛乳铁蛋白(bovine lactoferrin，bLF)对感染轮状病毒树鼩的治疗作用。方法 建立感染轮状病毒动物模型后，用不同剂量bLF的对腹泻树鼩进行治疗，各给药组和对照组经过连续给药10 d后用电镜法观察粪便中的轮状病毒，并计算轮状病毒的抗原检出率及抗原滴度及动物死亡率、平均死亡日、延长生命率。结果 bLF高、中、低剂量组的死亡率分别为10％，20％，60％；平均死亡日分别为9.3，8.9，7.0 d：延长生命率分别为93.7％，85.4％，45.8％。与模型对照组死亡率70％、平均死亡日4.8 d均有显著差异。治疗后，抗原滴度下降。结论 乳铁蛋白能有效的降低感染轮状病毒动物的死亡率，提高感染轮状病毒动物的延长生命率。同时能降低轮状病毒抗原滴度。

Abstract:

OBJECTIVE To observe the effect of bovine lactoferrin(bLF) on the treatment of rotavirus-infected tree shrew. METHODS After establishment of animal model of tree threw with totavirus-infected, the animal model was treated with distinct doses of bLF. RESULTS The death rates of totavirus-infected tree shrew in bLF treatment group with high, middle and low doses were 10%, 20% and 60%.The mean days of death were 9.3, 8.9, 7.0 d. The rate of the prolonged survival time were 93.7%, 85.4%, 45.8%. Compared with infection-control group with no bLF treatment, the death rates and the mean days of death were reduced remarkably. CONCLUSION bLF can reduce the mortality rate of rotavirus infections of animals effectively and improve the life-prolonging rate, which can also reduce the rotavirus antigen titer.