| 摘要: |
| 目的 合成盐酸氨溴索并改进合成工艺。方法 以2-氨基苯甲酸甲酯作为起始原料，经溴代、还原、氧化、缩合、成盐等反应制得盐酸氨溴索。结果 所得产物经核磁共振氢谱、质谱、红外等确证其结构，总收率为54.6%。结论 该工艺原料易得，方法简便，总杂<0.1%，适合工业化生产。 |
| 关键词: 盐酸氨溴索 祛痰药 合成 |
| DOI： |
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| Synthesis for Ambroxol Hydrochloride |
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1.河南大学药学院，河南 开封 475000；2.天津药物研究院化学制药部，天津 3001931,2
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1.School of Pharmacy, Henan University, Kaifeng 475000, China;2.Centre for Chemical Pharmaceutical Research, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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| Abstract: |
| OBJECTIVE To synthesis ambroxol hydrochloride and optimize the process. METHODS Ambroxol hydrochloride was synthesized from methyl 2-aminobenzoate via bromination, reduction, oxidation, condensation and salification. RESULTS Chemical structure of ambroxol hydrochloride was confirmed by 1H-NMR, MS and IR. The total yield of ambroxol hydrochloride was 54.6%. CONCLUSION The starting materials are easy to get and the method is simple. The total impurities content are <0.1%, and the method is suitable for industry. |
| Key words: ambroxol hydrochloride expectorants synthesis |
