| 引用本文: | 王利胜,程龙,吴阳,张升,田瑶.星点设计-效应面法优化盐酸普罗帕酮缓释片处方[J].中国现代应用药学,2012,29(11):998-1001. |
| WANG Lisheng,CHENG Long,WU Yang,ZHANG Sheng,TIAN Yao.Optimization of Propafenone Hydrochloride Sustained-release Tablets by Central Composite Design and Response Surface Methodology[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(11):998-1001. |
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| 摘要: |
| 目的 采用星点设计-效应面法优化盐酸普罗帕酮缓释片的处方。方法 以羟丙基甲基纤维素、乳糖的用量为考察因素，体外累积释放度为考察指标，选用星点设计-效应面法优化处方，并对结果进行验证。结果 优化处方中羟丙基甲基纤维素和乳糖的用量分别为31.19%~32.16%，8.67%~14.7%，预测值与实测值的偏差均在6%以内。结论 通过星点设计-效应面法建立的模型可用于盐酸普罗帕酮缓释片的优化，所建立的数学模型具有准确的预测性。 |
| 关键词: 盐酸普罗帕酮 星点设计-效应面法 羟丙基甲基纤维 缓释片 |
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| Optimization of Propafenone Hydrochloride Sustained-release Tablets by Central Composite Design and Response Surface Methodology |
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WANG Lisheng, CHENG Long, WU Yang, ZHANG Sheng, TIAN Yao
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College of Chinese Pharmacy, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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| Abstract: |
| OBJECTIVE To optimize the formulation of propafenone hydrochloride sustained-release tablets by central composite design/response surface methodology. METHODS The formulation of propafenone hydrochloride sustained-release tablets was optimized using the amount of HPMC and lactose as factors and with accumulative release rate as index. The optimized results were validated. RESULTS Optimized formulation was 31.19%-32.16% by HPMC and 8.67%-14.7% by lactose. Bias between the observed and predicted values was within 6%. CONCLUSION The model developed by central composite design/response surface methodology can be used for the optimization of propafenone hydrochloride sustained-release tablets formulation. Established model has good predictive accuracy. |
| Key words: propafenone hydrochloride central composite design/response surface methodology HPMC sustained-release tablet |
