| 引用本文: | 林冰,周英,王慧娟,田源,詹先成.台阶型变湿变温法对固体哌拉西林钠的稳定性研究[J].中国现代应用药学,2012,29(8):718-721. |
| LIN Bing,ZHOU Ying,WANG Huijuan,TIAN Yuan,ZHAN Xiancheng.Stability Studies on Solid Piperacillin Sodium with Stepped Humidity and Temperature Controlled Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(8):718-721. |
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| 摘要: |
| 目的 建立台阶型变湿变温法对固体药物的稳定性研究方法。方法 以哌拉西林钠为模型，采用台阶型变湿变温法研究哌拉西林钠的降解动力学过程。结果 得到了哌拉西林钠降解过程的动力学参数A、m及Ea，与经典恒温恒湿法比较，结果一致。结论 台阶法可用于哌拉西林钠的降解动力学研究，是否能用于其它固体药物还需进一步研究。 |
| 关键词: 哌拉西林钠 台阶型变湿变温法 稳定性 湿度 降解动力学 |
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| 基金项目:贵州省科学技术基金(黔科合J字[2009]2293)；贵州大学引进人才科研项目[贵大人基合字(2008)009] |
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| Stability Studies on Solid Piperacillin Sodium with Stepped Humidity and Temperature Controlled Method |
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LIN Bing1, ZHOU Ying1, WANG Huijuan1, TIAN Yuan1, ZHAN Xiancheng2
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1.College of Life Sciences, Guizhou University, Guiyang 550025, China;2.West China School of Pharmacy, Sichuan University, Chengdu 610041, China
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| Abstract: |
| OBJECTIVE To establish the stepped humidity and temperature controlled method for stability study of solid drugs. METHODS The stepped humidity and temperature controlled method was used to study the degradation kinetics of piperacillin sodium. RESULTS The kinetic parameters of A, m and Ea obtained in the stepped humidity and temperature experi- ments were comparable with those obtained in the experiments at constant humidity and temperature. CONCLUSION The stepped humidity and temperature method was applicable to the stability study of piperacillin sodium. However, applications of the stepped humidity and temperature method to other solid drugs were uncertain. |
| Key words: piperacillin sodium stepped humidity and temperature controlled method stability humidity degradation kinetics |
