安宫牛黄丸对急性脑梗死患者血浆BNP与CRP浓度影响及疗效观察

Effects of Angong Niuhuang Pills on Plasma BNP and CRP and Neurological Functional Defect in Patients with Acute Cerebral Infarction

关键词:  安宫牛黄丸  急性脑梗死  脑钠肽  C反应蛋白

Key words:  Angong Niuhuang pill  acute cerebral infarction  brain natriuretic peptide  C reactive protein

摘要:

目的 观察安宫牛黄丸对急性脑梗死患者神经功能缺损的改善作用及血清脑钠肽(BNP)、C反应蛋白(CRP)水平的影响。方法 将136例急性脑梗死患者随机分为治疗组(70例)和对照组(66例)。在两组均予常规西药治疗的基础上，治疗组加用安宫牛黄丸，1天1丸，口服或鼻饲，7 d为1疗程。在治疗前及治疗后30 d分别对两组的神经功能缺损进行评分，并在治疗前及治疗后7 d分别检测两组血浆BNP，CRP水平。结果 两组治疗后神经功能缺损都有显著改善(P<0.05)，其中治疗组神经功能缺损改善优于对照组(P<0.05)；两组治疗后血浆BNP，CRP水平均显著下降(P<0.05)，其中治疗组下降值明显高于对照组。结论 安宫牛黄丸有助改善急性脑梗死患者神经功能缺损，可能通过降低脑梗死后血浆BNP，CRP水平发挥作用。

Abstract:

OBJECTIVE To investigate the effects of Angong Niuhuang pill on serum BNP and CRP and neurological functional defect in patients with acute cerebral infarction. METHODS Totally 136 patients with acute cerebral infarction were randomized into treatment group (70 cases) and control group (66 cases). Both groups were given routine western medicines, the treatment group was given an additional oral administration (or nasal feeding) of Angong Niuhuang pill(1 pill a day) for 7 days. Before treatment and after 30 days’ treatment, each group was graded the neural function defect separately, and before treatment and after 7 days’ treatment, plasma BNP and CRP levels were measured separately. RESULTS After treatment both groups had significant neurological functional improvements(P<0.05), the neurological functional defect was recovered more markedly in treatment group compared with the control group(P<0.05). After treatment, plasma BNP and CRP levels in both groups decreased significantly(P<0.05), which decreased more markedly in treatment group compared with control group(P<0.05). CONCLUSION Angong Niuhuang pill helps to improve neural function in patients with acute cerebral infarction by reducing plasma BNP and CRP levels.