健脾消胀片对大鼠胃酸含量、胃蛋白酶活力及胃肠电活动影响

Effect of Jianpi Xiaozhang Tablets on Content of Rat Gastric Acid, Pepsin Activity and Gastrointestinal Electrical Activity

关键词:  健脾消胀片  胃酸  胃蛋白酶  胃肠电活动  保和丸  多潘立酮

Key words:  Jianpi Xiaozhang tablets  gastric acid  pepsin  gastrointestinal electrical activity  Baohe pills  domperidone tablets

摘要:

目的 探讨健脾消胀片对大鼠胃酸含量、胃蛋白酶活力及胃肠电活动的影响。方法 结扎大鼠幽门与十二指肠结合部造模，测大鼠胃酸含量和胃蛋白酶活力；用EGEG-8D胃肠电图仪记录5 min大鼠胃电图，测量频率和幅值，以观察健脾消胀片对大鼠胃窦电活动、小肠电活动的影响。结果 大、中剂量健脾消胀片组可使大鼠胃酸含量显著升高，大剂量健脾消胀片组可使大鼠胃蛋白酶活性显著升高，中剂量健脾消胀片组可使大鼠胃蛋白酶活性明显升高；大、中剂量健脾消胀片组可使大鼠胃窦电活动频率显著升高，小剂量健脾消胀片组可使大鼠胃窦电活动频率明显升高，大、中、小剂量健脾消胀片组可使大鼠胃窦电活动幅值显著升高；大、中、小剂量健脾消胀片组可使大鼠小肠电活动频率和幅值均显著升高。结论 健脾消胀片具有消食和胃的临床意义。

Abstract:

OBJECTIVE Study effects of Jianpi Xiaozhang tablets on content of gastric acid, pepsin activity and gastric electrical activity in rats. METHODS Ligation pyloric and duodenal junction of rats, measuring content of rat gastric acid and pepsin activity; Record 5 min electrogastrogram with EGEG-8D gastrointestinal electrical instrument, measuring frequency and amplitude to observate the impact of Jianpi Xiaozhang tablet on rat antral electrical activity, electrical activity of small intestine. RESULTS The groups of medium and high doses of Jianpi Xiaozhang tablets could make the rat gastric acid content increased significantly, the group of high dose of Jianpi Xiaozhang tablets made the pepsin activity in rats significantly increased, the groups of medium and high doses of Jianpi Xiaozhang tablets could make the pepsin activity in rats significantly elevated. The groups of medium and high doses of Jianpi Xiaozhang tablets made rat antral electrical activity frequency increased significantly. The group of low dose of Jianpi Xiaozhang tablets could make the rat antral electrical activity significantly elevated. The groups of low, medium and high doses of Jianpi Xiaozhang tablets could make the rat antral electrical activity significantly higher in large amplitude. The groups of low, medium and high doses of Jianpi Xiaozhang tablets made frequency and amplitude of the rat small intestinal electric activity significantly elevated. CONCLUSION Jianpi Xiaozhang tablets have clinical significance to promote digestion.