| 引用本文: | 李晶佳,云彩鳞,刘小雷.治疗SLE靶向新型制剂的回顾与进展[J].中国现代应用药学,2013,30(3):333-337. |
| LI Jingjia,YUN Cailin,LIU Xiaolei .Review and Progress of Target Drugs in the Treatment of Systemic Lupus Erythematous[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(3):333-337. |
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| 摘要: |
| 系统性红斑狼疮(systemic lupus erythematous，SLE)的发病机制复杂，临床表现多样化。目前SLE的治疗主要以激素和免疫抑制剂的联用为主，近年来，细胞乃至分子生物学的发展使SLE的发病机制得到新的阐述，从而涌现出了一大批通过调节T、B细胞治疗SLE的靶向药生物制剂。本文对此类药物的研究进展进行了一个综合性的论述，为SLE药物的临床应用提供阶段性的参考。 |
| 关键词: 系统性红斑狼疮 药物治疗 靶向药物 |
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| Review and Progress of Target Drugs in the Treatment of Systemic Lupus Erythematous |
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LI Jingjia, YUN Cailin, LIU Xiaolei
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Pharmacology College of Inner Mongolia Medical University, Inner Mongolia, Hohhot 010059, China
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| Abstract: |
| As the disease with complex symptom and poorly understanding pathology, treatment of systemic lupus erythematous (SLE) is still mainly based on “traditional” drugs, corticosteroids and immunosuppressive. However the mechanism of SLE has been promoted to several levels and provided a brand new clue of target treatment. The research and exploration on biological agents has been put efforts, thus a large number of biological drugs emerged due to regulate the activation of T and B cell through many aspects of immune reaction. The article will present the drugs of each classification and apply an temporary reference for clinical medical therapy guidance. |
| Key words: SLE medication associated mechanism |
