| 引用本文: | 胡静波,董少华,苏卫,胡晓,陈鹰.阿魏酸钠胃内漂浮片的制备及体外释放机制考察[J].中国现代应用药学,2013,30(1):43-47. |
| HU Jingbo,DONG Shaohua,SU Wei,HU Xiao,CHEN Ying.Preparation and in Vitro Release Study of Sodium Ferulate Gastric Floating Tablets[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(1):43-47. |
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| 阿魏酸钠胃内漂浮片的制备及体外释放机制考察 |
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胡静波1,2, 董少华1,3, 苏卫1,2, 胡晓1,3, 陈鹰1
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1.广州军区武汉总医院，武汉 430070;2.南方医科大学，广州 510515;3.湖北中医药大学，武汉 430065
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| 摘要: |
| 目的 优化阿魏酸钠胃内漂浮片的制备工艺，并对其体外释药机理进行研究。方法 以HPMC K4M为亲水性凝胶骨架，十六醇为助漂剂，NaHCO3为产气剂，采用星点设计-效应面法对处方进行优化，并通过方程拟合探讨释药机制。结果 优化得到最优处方，所制得胃内漂浮片均能在1 min内起漂，持续漂浮10 h。结论 采用星点设计-效应面法优化的处方预测性良好，并且所制得的胃内漂浮片具有良好的漂浮和控释能力。 |
| 关键词: 阿魏酸钠 胃内漂浮片 制备 星点设计-效应面法 |
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| Preparation and in Vitro Release Study of Sodium Ferulate Gastric Floating Tablets |
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HU Jingbo1,2, DONG Shaohua1,3, SU Wei1,2, HU Xiao1,3, CHEN Ying1
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1.Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China;2.Southern Medical University, Guangzhou 510515, China;3.Hubei University of Chinese Medicine, Wuhan 430065, China
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| Abstract: |
| OBJECTIVE To optimize the preparation technique of gastric floating tablets of sodium ferulate and study the release mechanism of diammonium glycyrrhizinate release from the tablet. METHODS The gastric floating tablets were prepared with HPMC K4M as gel-matrix, cetyl alcohol as floating-assistant, NaHCO3 as gas-producer. The formulation was optimized by central composite design-response surface methodology. Release mechanism of diammonium glycyrrhizinate from gastric floating tablets was established by equation fitting. RESULTS Optimized formulation region of gastric floating tablets were found. The initial floating time was less than 1 min and the durative floating time was more than 10 h. CONCLUSION Central composite design were successful in optimizing the preparation of tablets with accurate and gastric floating tablets had good floating and sustained release ability. |
| Key words: sodium ferulate gastric floating tablet preparation central composite design-response surface methodology |
