摘要: |
三氧化二砷(As2O3,ATO)在治疗人类急性早幼粒细胞白血病(APL)中发挥了不可替代的作用,鉴于其突出的医疗价值,人们在不同类型的癌症治疗中对其进行了应用。作为一个多靶点、多通路的治疗药物,ATO的应用尚有争论。无论如何,明确其药物作用机制,对进一步开展相关研究意义重大。本文就此做一综述。 |
关键词: 三氧化二砷 癌症 |
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Mechanisms of Arsenic Trioxide Used in Cancers Therapy |
LIU Huan, Narenmandura
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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Abstract: |
Arsenic trioxide(As2O3,ATO) is one of the most effective therapeutic agents for patient with acute promyelocytic leukemia(APL), common but irreplaceable. Depending on its potential values, it has also been developed for treatment of other forms of tumors (e.g. liver and lungs cancer). Although As2O3
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Key words: arsenic trioxide cancer |