| 引用本文: | 阚红玉,尹俏,刘彦莉,孙玉侠,曹凤兰.GC测定藿香正气滴丸中百秋李醇的含量[J].中国现代应用药学,2013,30(7):762-764. |
| KAN Hongyu,YIN Qiao,LIU Yanli,SUN Yuxia,CAO Fenglan.Quantitative Determination of Patchouli Alcohol in Huoxiang Zhengqi Dripping Pill By GC[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(7):762-764. |
|
| 摘要: |
| 目的 建立藿香正气滴丸中百秋李醇的含量测定方法。方法 采用气相色谱法测定处方中广藿香油的含量。色谱条件：固定相以5%苯基95%二甲基聚硅氧烷为填料的毛细管柱，检测器为FID氢火焰离子化检测器；进样口温度：280 ℃；检测器温度：280 ℃；柱温：165 ℃，程序升温，载气：氮气；分流进样；分流比：5∶1；进样量：1 mL。结果 百秋李醇在0.030 0~0.961 0 μg(r=0.999 9)内峰面积与其进样量线性关系良好；百秋李醇平均回收率为101.1%，RSD为1.45%；样品溶液在24 h内稳定。结论 该方法快捷、准确，重复性好，能够用于藿香正气滴丸的质量控制。 |
| 关键词: 藿香正气滴丸 气相色谱法 百秋李醇 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Quantitative Determination of Patchouli Alcohol in Huoxiang Zhengqi Dripping Pill By GC |
|
KAN Hongyu, YIN Qiao, LIU Yanli, SUN Yuxia, CAO Fenglan
|
|
Tasly Pharmaceutical Group CO. LTD, Tianjin 300410, China
|
| Abstract: |
| OBJECTIVE To determine the content of Patchouli alcohol in Huoxiang Zhengqi Dripping Pill by GC. METHODS The GC separation was performed on capillary gas chromatographic column; FID flame ionization detector; carrier gas is nitrogen; temperature setting: sampling input temperature 280 ℃; column temperature 165 ℃,temperature programming process; detector temperature 280 ℃; split ratio: 5∶1; sample size: 1 μL. RESULTS In the GC experiments of precision, reproducibility and stability, the samples could be separated entirely. For patchouli alcohol, the linear range was 0.030 0-0.961 0 μg(r=0.999 9), the average recoveries were 101.1% with RSD=1.45% and it was stable in 24 h. CONCLUSION The method was sensitive, simple, accurate and reproducible, can be used to control the quality of Huoxiang Zhengqi Dripping Pill. |
| Key words: Huoxiang zhengqi dripping Pill GC patchouli alcohol |
