宁心通痹胶囊对犬试验性心肌缺血的影响

Effects of Ningxin Tongbi Capsule on Acute Myocardial Ischemia of Dogs

关键词:  宁心通痹胶囊  心肌缺血  血流动力学

Key words:  Ningxin Tongbi capsule  acute myocardial ischemia  hemodynamic parameters

摘要:

目的 采用犬实验性心肌缺血模型，观察宁心通痹胶囊抗心肌缺血的作用。方法 30只犬随机分成5组：模型对照组(注射生理盐水)、阳性对照组(20 mg·kg^-1地奥心血康胶囊)、宁心通痹胶囊低中高剂量组。每组6只犬。结扎冠脉左前降支建立犬急性心肌缺血模型，观测心肌梗死范围、心电图、血流动力学及相关酶学指标等。结果 宁心通痹胶囊在1.02，2.04 g·kg^-1剂量下，对犬心肌缺血模型具有改善心电图S-T段偏移量，增加冠脉流量和心输出量，升高左心室收缩压作用，亦能缩小心肌梗死面积，改善心肌酶学等指标的异常。结论 宁心通痹胶囊对犬心肌缺血具有明显的防治作用。

Abstract:

OBJECTIVE To observe the preventive effects of Ningxin Tongbi capsule on acute myocardial ischemia in dogs. METHOD Thirty dogs were randomly divided into model group(physiological saline solution), Diaoxinxuekang capsule group(20 mg·kg^-1), Ningxin Tongbi capsule low dose, median dose and high dose group, 6 dogs per group. The left downwards coronary arterys of dogs were ligated to establish the acute myocardial ischemia model. Electrocardiogram, some hemodynamic parameters and cardiac oxygen consumption were dectected before and after the stomach lavage. The area of myocardial infarction was determined by NBT immunohisto chemistry. RESULTS Compared with model group, at the dose of 1.02, 2.04 g·kg^-1, Ningxin Tongbi capsule could degrade the S-T migration of electrocardiogram, and increase coronary artery blood flow, CO and LVSP, relieve the infarction areas and levels of serum CK, LDH significantly(P<0.05 or P<0.01). CONCLUSION Ningxin Tongbi capsule has the remarkable protective effects of anti-myocardial ischemia and can protect myocardial cells.