| 引用本文: | 张晓云,赵鹏,乔华,倪京满,史彦斌.双氢青蒿素磷脂复合物的研究[J].中国现代应用药学,2013,30(6):636-641. |
| ZHANG Xiaoyun,ZHAO Peng,QIAO Hua,NI Jingman,SHI Yanbin.Study on Dihydroartemisinin Phospholipid Complex[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(6):636-641. |
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| 摘要: |
| 目的 优化双氢青蒿素(dihydroartemisinin，DHA)与磷脂形成复合物的制备工艺。方法 以DHA磷脂复合物的复合率为评估标准，采用单因素和正交设计试验考察各因素对复合率的影响；并用高效液相色谱法测定DHA磷脂复合物中DHA的含量。结果 DHA磷脂复合物的最优制备条件为55 ℃制备温度下，以氯仿为反应溶剂，DHA与磷脂的投料比为1∶3，药物浓度为5%，反应时间为3 h。结论 在55 ℃制备温度下DHA磷脂复合物的形成受溶剂、反应物投料比、药物浓度及反应时间的影响较大。 |
| 关键词: 双氢青蒿素 磷脂复合物 正交设计 制备工艺 |
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| Study on Dihydroartemisinin Phospholipid Complex |
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ZHANG Xiaoyun1, ZHAO Peng2, QIAO Hua3, NI Jingman1, SHI Yanbin1
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1.School of Pharmacy, Lanzhou University, Lanzhou 730000, China;2.The First Hospital of Lanzhou University, Department of Oncology, Lanzhou 730000, China;3.The First Hospital of Lanzhou University, Department of Pharmaceutics, Lanzhou 730000, China
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| Abstract: |
| OBJECTIVE To optimize the preparing condition of dihydroartemisinin-phospholipid complex. METHODS The single factor experiment and orthogonal design was used to optimize preparation technology of the complex by using the combining ratio as the assessment index. In addition, the content of dihydroartemisinin in dihydroartemisinin-phospholipid complex was determined by HPLC. RESULTS The optimal preparing conditions for dihydroartemisinin-phospholipid complex was the ratio of dihydroartemisinin to phospholipid of 1∶3, dihydroartemisinin concentration of 5%, the reaction time of 3 h, and the solvent of chloroform and the reaction temperature at 55 ℃. CONCLUSION Dihydroartemisinin-phospholipid complex was affected by solvent, the ratio of dihydroartemisinin to phospholipid, dihydroartemisinin concentration and reaction time at 55 ℃. |
| Key words: dihydroartemisinin phospholipid complex orthogonal design preparation technology |
