丙泊酚全麻对胆道手术患者血清IL-2和IL-6的影响

高小茜; 陈先亲; 章宦飞; 缪荣华; 陈如品; 蔡万雷; 韩必亮; 邱招涨

引用本文:	高小茜,陈先亲,章宦飞,缪荣华,陈如品,蔡万雷,韩必亮,邱招涨.丙泊酚全麻对胆道手术患者血清IL-2和IL-6的影响[J].中国现代应用药学,2013,30(6):687-690.
	GAO Xiaoxi,CHEN Xianqin,ZHANG Huanfei,MIAO Ronghua,CHEN Ruping,CAI Wanlei,HAN Biliang,QIU Zhaozhang.Influence of Propofol Anesthesia in Serum IL-2 and IL-6 Levels of Patients with Biliary Tract Surgery[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(6):687-690.

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丙泊酚全麻对胆道手术患者血清IL-2和IL-6的影响
高小茜¹, 陈先亲¹, 章宦飞¹, 缪荣华¹, 陈如品¹, 蔡万雷¹, 韩必亮², 邱招涨²
1.苍南县第二人民医院麻醉科，浙江温州 325802;2.苍南县第二人民医院普外科，浙江温州 325802

摘要:

目的探讨丙泊酚全凭静脉全麻对胆道手术患者围术期血清细胞因子IL-2和IL-6的影响。方法 30例择期行开腹胆道手术患者，随机分为七氟烷吸入全麻组(S组)和丙泊酚全凭静脉全麻组(P组)，每组各15例。分别于麻醉诱导前(T₀)、术毕(T₁)、术后24 h(T₂)、术后72 h(T₃)采集静脉血3 mL，酶标法测定血清IL-2、IL-6水平。结果与T₀时段相比，2组T₁时段血清IL-2显著下降(P<0.05)，T₁、T₂时段血清IL-6显著升高(P<0.05)。与P组比较，T₁时段S组血清IL-6的显著升高(P<0.05)。结论七氟烷和丙泊酚对血清IL-2水平变化影响无显著差别。丙泊酚全凭静脉全麻显著抑制血清IL-6水平升高，抑制手术麻醉应激引起的免疫反应。

关键词: 七氟烷丙泊酚胆道手术白介素-2 白介素-6

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Influence of Propofol Anesthesia in Serum IL-2 and IL-6 Levels of Patients with Biliary Tract Surgery

GAO Xiaoxi¹, CHEN Xianqin¹, ZHANG Huanfei¹, MIAO Ronghua¹, CHEN Ruping¹, CAI Wanlei¹, HAN Biliang², QIU Zhaozhang²

1.Secon People’s Hospital of Cangnan County, Anesthesiology, Wenzhou 325802, China;2.Secon People’s Hospital of Cangnan County, General Surgery, Wenzhou 325802, China

Abstract:

OBJECTIVE To explore the influence propofol total intravenous anesthesia perioperative serum cytokines IL-2 and IL-6 in patients with biliary tract surgery. METHODS Thirty patients undergoing biliary surgery surgery were randomly divided into sevoflurane anesthesia (Group S ) and propofol total intravenous anesthesia group (Group P), 15 cases in each group. Serum samples were collected before induction of anesthesia (T0), surgery completed (T1), postoperative 24h (T2), postoperative 72h (T3), respectively. Serum levels of IL-2, IL-6 level were measured by ELISA method. RESULTS In T1 period, serum IL-2 of the two groups was significantly decreased compared with T0 (P<0.05), while in T1 and T2 period, serum IL-6 of the two groups was significantly higher (P<0.05). Compared with Group P, serum IL-6 of the Group S was significantly increased in T1(P<0.05). CONCLUSION The influence of sevoflurane and propofol on serum IL-2 level have no significant difference. Propofol total intravenous anesthesia significantly suppressed serum IL-6 levels, and inhibited the immune response induced by surgical stress.

Key words: sevoflurane propofol biliary surgery interleukin-2 interleukin-6