| 引用本文: | 张玉军,莫志江.文献中正交试验的常见问题分析和解决方法[J].中国现代应用药学,2013,30(6):696-700. |
| ZHANG Yujun,MO Zhijiang.Common Mistakes Made in Some Literatures When Performing Orthogonal Experiments and Solutions[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(6):696-700. |
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| 摘要: |
| 目的 提高正交试验的质量和实用性。方法 对文献报道的正交试验进行总结分析。结果 部分正交试验存在的问题和后果是：无空白列导致夸大随机效应；无理由忽略交互作用导致混杂现象；手工计算导致方差分析错误；最优工艺不考虑成本因素导致无谓增加生产成本。结论 正交试验应该留有空白列；否定交互作用的存在应该有实验或文献的支持；应该使用专业统计软件分析数据以确保结果的准确性；工艺考察应包括成本-效益评估。 |
| 关键词: 正交试验 方差分析 混杂现象 成本-效益 |
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| 基金项目:广西壮族自治区卫生厅课题(Z2010256) |
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| Common Mistakes Made in Some Literatures When Performing Orthogonal Experiments and Solutions |
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ZHANG Yujun1, MO Zhijiang2
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1.Medicines and Medical Equipment Centralized Purchasing Service Center of Guangxi Zhuang Autonomous Region, Nanning 530021, China;2.Pharmacy Department, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| OBJECTIVE To improve the quality and utility of orthogonal experiments. METHODS The orthogonal experiments in published literatures were reviewed. RESULTS The common mistakes made in some literatures and outcomes were: orthogonal design or orthogonal table without blank column, resulting in inflating the random effect; baselessly ignoring the interactions, resulting in confounding bias; wrong results of analysis of variance (ANOVA) because of manual calculation; the selection of optimal process without considering cost-effectiveness, incurring cost increase of manufacturing. CONCLUSION Blank column of orthogonal table should be reserved for error estimated; the interactions could be ignored only when their existence are denied in relevant experiments and literatures; the data of orthogonal experiments should be analyzed using statistical software to make sure the accuracy of the results, and the cost-effectiveness should be considered in the selection of optimal process. |
| Key words: orthogonal experiment analysis of variance(ANOVA) confounding bias cost-effectiveness |
