| 引用本文: | 李洪阳,常惟志,段东升,闫玉芹,姜立丽,马宁,陈璐璐,肖光玲,高宇,李彦冰.Box-Behnken设计-效应面法优化降糖1号胶囊的提取工艺[J].中国现代应用药学,2013,30(9):981-984. |
| LI Hongyang,CHANG Huaizhi,DUAN Dongsheng,YAN Yuqin,JIANG Lili,MA Ning,CHEN Lulu,XIAO Guangling,GAO Yu,LI Yanbing.Optimization of Extractive Technology for Jiangtangyihao Capsule by Box-Behnken Design-Response Surface Methodology[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(9):981-984. |
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| Box-Behnken设计-效应面法优化降糖1号胶囊的提取工艺 |
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李洪阳1, 常惟志1, 段东升2, 闫玉芹2, 姜立丽1, 马宁1, 陈璐璐1, 肖光玲1, 高宇1, 李彦冰1
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1.黑龙江中医药大学，哈尔滨 150040;2.哈尔滨溢康中医药研究所，哈尔滨 150036
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| 摘要: |
| 目的 优选降糖1号胶囊的提取工艺。方法 水回流提取，以提取时间、提取次数、料液比为考察因素，总黄酮得率为考察指标，采用Box-Behnken设计试验，效应面法分析试验结果。结果 提取时间和提取次数对实验结果具有极显著的影响，料液比对试验结果具有显著性影响，最佳提取工艺为水回流提取3次，每次59 min，料液比为23 mL·g-1，实测总黄酮得率与预测总黄酮得率的相对偏差为-2.66%。结论 Box-Behnken设计-效应面法对该提取工艺的优化结果准确、合理、可行。 |
| 关键词: Box-Behnken 设计 效应面法 降糖1号胶囊 提取工艺 |
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| Optimization of Extractive Technology for Jiangtangyihao Capsule by Box-Behnken Design-Response Surface Methodology |
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LI Hongyang1, CHANG Huaizhi1, DUAN Dongsheng2, YAN Yuqin2, JIANG Lili1, MA Ning1, CHEN Lulu1, XIAO Guangling1, GAO Yu1, LI Yanbing1
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1.Heilongjiang University of Chinese Medicine, Harbin 150040, China;2.Harbin Yikang Institute of Chinese Medicine, Harbin 150036, China
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| Abstract: |
| OBJECTIVE To optimize the extractive technology of Jiangtangyihao capsule. METHODS Water reflux, extraction time, extraction times and solid-liquid ratio were observed as factors, total flavonoids was investigated as the indicator. Box-Behnken design-response surface methodology was used to analyze test data. RESULTS Extraction time and the number of extraction times had a very significant impact on the experimental results and the solid-liquid ratio had a significant impact on the test results. The optimum extraction conditions for Jiangtangyihao capsule were obtained as follows: extracting three times with water reflux extraction, each time was 59 min, the ratio of solid-liquid was 23 mL·g-1. Relative deviation between the measured yield of flavonoids and predicted total yield of flavonoids was -2.66%. CONCLUSION The extraction method was accurate, rational and feasible. |
| Key words: Box-Behnken design response surface methodology Jiangtangyihao capsule extractive technology |
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