| 引用本文: | 康小龙,何承辉,邢建国,闫丽丽.香青兰总黄酮对哮喘大鼠白细胞介素-6、13、17和肿瘤坏死因子-α的影响[J].中国现代应用药学,2013,30(8):839-842. |
| KANG Xiaolong,HE Chenghui,XING Jianguo,YAN Lili.Effects of Moldavica Total Flavone on Interleukin-6, 13, 17 and Tumor Necrosis Factor-α Levels in Asthma Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(8):839-842. |
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| 摘要: |
| 目的 观察香青兰总黄酮对哮喘大鼠肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、13、17等细胞因子水平的影响。方法 采用卵白蛋白致敏和激发建立大鼠哮喘模型，给予香青兰总黄酮进行干预后，ELISA法检测大鼠BALF中TNF-α、IL-6、IL-13和IL-17的含量。结果 香青兰总黄酮180和360 mg·kg-1·d-1可降低哮喘大鼠BALF中TNF-α、IL-6、IL-13和IL-17含量(P<0.05或P<0.01)。结论 香青兰总黄酮对哮喘TNF-α、IL-6、IL-13和IL-17等炎症因子的释放具有一定抑制作用。 |
| 关键词: 香青兰总黄酮 肿瘤坏死因子-α 白介素-6 白介素-13 白介素-17 |
| DOI： |
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| 基金项目:新疆维吾尔自治区自然科学基金(2011211A098) |
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| Effects of Moldavica Total Flavone on Interleukin-6, 13, 17 and Tumor Necrosis Factor-α Levels in Asthma Rats |
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KANG Xiaolong1, HE Chenghui2, XING Jianguo2, YAN Lili2
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1.Hospital of Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi 830000, China;2.Xinjiang Medicine Research Instirute, Urumqi 830004, China
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| Abstract: |
| OBJECTIVE To investigate the effects of moldavica total flavone on interleukin-6, 13, 17 and tumor necrosis factor-α levels in ovalbumin-induced asthmatic rats. METHODS Rats asthma model was established by ovalbumin challenge methods. After therapy by moldavica total flavone, TNF-α, IL-6, IL-13 and IL-17 in BALF were detected respectively by ELISA. RESULTS The levels of TNF-α, IL-6, IL-13 and IL-17 in BALF were markedly decreased(P<0.05 or P<0.01) after administration of 180 and 360 mg·kg-1·d-1 moldavica total flavone in ovalbumin-induced asthmatic rats. CONCLUSION Moldavica total flavone can inhibit the release of inflammatory cytokines of TNF-α, IL-6, IL-13 and IL-17 on asthma. |
| Key words: moldavica total flavone tumor necrosis factor-α interleukin-6 interleukin-13 interleukin-17 |
