α-萜品烯醇对佐剂性关节炎大鼠的治疗作用

Effects of α-Terpineol on Arthritis of Adjuvant Arthritis Rats

关键词:  α-萜品烯醇  佐剂性关节炎  关节肿胀率  IL-4  IFN-γ

Key words:  α-terpineol  adjuvant arthritis  degree of joints swelling  IL-4  IFN-γ

摘要:

目的 探讨α-萜品烯醇对弗氏完全佐剂诱导的大鼠佐剂性关节炎的作用及其机制。方法 建立弗氏完全佐剂诱导的大鼠关节炎模型。用0.18，0.35，0.7 mg·kg^-1的α-萜品烯醇进行治疗，同时设雷公藤多苷组(阳性对照组)、模型组和空白对照组。比较各组关节肿胀率变化，血清IL-4和IFN-γ含量及病变关节损害程度。结果 α-萜品烯醇0.35，0.7 mg·kg^-1组、雷公藤多苷组可减轻关节炎症状，降低关节肿胀率(P<0.01)，调节IFN-γ、IL-4水平。结论 α-萜品烯醇能有效改善大鼠关节炎症状，减轻关节肿胀率，降低IFN-γ水平，升高IL-4水平。

Abstract:

OBJECTIVE To study the effects of α-terpineol on adjuvant arthritis(AA) rats induced by Freund's complete adjuvant. METHODS After establishment of animal model of adjuvant arthritis, the rats were treated with 0.18, 0.35, 0.7 mg·kg^-1 α-terpineol, and the tripterygium glycosides group, model group, and control group were set as well. The degree of joints swelling, the level of IFN-γ, IL-4 in these groups were observed. RESULTS Compared with the model group, in the 0.35, 0.7 mg·kg^-1 α-terpineol group and the tripterygium glycosides group, the degree of joints swelling was obviously decreased(P<0.01), and the level of IFN-γ, IL-4(P<0.05) was adjusted. CONCLUSION α-Terpineol can effectively improve the symptoms of AA rats and reduce the degree of joint swelling, may be due to its upregulation of the level of IL-4, and down regulation of the level of IFN-γ.